{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T06:17:48Z","timestamp":1783145868574,"version":"3.54.6"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":71,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Clinical Key Specialty Construction Project","award":["shslczdzk06504"],"award-info":[{"award-number":["shslczdzk06504"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Insufficient data exist regarding the investigation of the impact of novel oral anticoagulants (NOACs) on coagulation activation biomarkers in the context of left atrial appendage closure (LAAC) and device\u2010related thrombosis (DRT). The study was designed to investigate the changes and presence of coagulation activation biomarkers between different antithrombotic strategies following LAAC. A total of 120 nonvalvular atrial fibrillation patients intolerant of long\u2010term anticoagulants, who underwent successful WATCHMAN closure implantation, were enrolled (rivaroxaban, <jats:italic>n<\/jats:italic> = 82; dabigatran, <jats:italic>n<\/jats:italic> = 38). Blood samples were obtained from left atrium (LA) and left atrial appendage (LAA) during the operation and fasting blood samples on the same day of LAAC and 45 days after discharge. The biochemical indicators, thrombin\u2010antithrombin complex (TAT), soluble P\u2010selectin (sP\u2010selectin), von Willebrand factor (vWF), and CD40 ligand (CD40L), were measured by enzyme\u2010linked immunosorbent assay. The primary endpoints of this study were the efficacy and safety characteristics of different antithrombotic strategies, including DRT incidence, stroke or transient ischemic attack, systemic embolism, and clinical major and nonmajor bleeding complications during the follow\u2010up of 180 days. The results revealed that TAT, vWF, sP\u2010selectin, and CD40L levels in vein were significantly reduced by 2.4% (<jats:italic>p<\/jats:italic> = 0.043), 5.0% (<jats:italic>p<\/jats:italic> &lt; 0.001), 8.7% (<jats:italic>p<\/jats:italic> &lt; 0.001), and 2.5% (<jats:italic>p<\/jats:italic> = 0.043) from their baseline levels after rivaroxaban treatment. Conversely, no significant changes were detected in the dabigatran group. Furthermore, the plasma levels of platelet activation biomarkers (CD40L and sP\u2010selectin) in both LA and LAA groups were significantly lower after anticoagulation with rivaroxaban, as compared to dabigatran treatment (CD40L: 554.62 \u00b1 155.54 vs. 445.02 \u00b1 130.04 for LA <jats:italic>p<\/jats:italic> = 0.0013, 578.51 \u00b1 156.28 vs. 480.13 \u00b1 164.37 for LAA <jats:italic>p<\/jats:italic> = 0.0052; sP\u2010selectin: 2849.07 \u00b1 846.69 vs. 2225.54 \u00b1 799.96 for LA <jats:italic>p<\/jats:italic> = 0.0105, 2915.52 \u00b1 1402.40 vs. 2203.41 \u00b1 1061.67 for LAA <jats:italic>p<\/jats:italic> = 0.0022). Notably, the present study suggests that rivaroxaban may be more effective in the prevention of DRT for patients undergoing LAAC.<\/jats:p>","DOI":"10.1155\/2024\/4405152","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T23:50:06Z","timestamp":1710287406000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Perioperative Treatment with Rivaroxaban and Dabigatran on Changes of Coagulation and Platelet Activation Biomarkers following Left Atrial Appendage 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