{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:36:00Z","timestamp":1782398160088,"version":"3.54.5"},"reference-count":107,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":175,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Nephrology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>IgG4\u2010related disease (IgG4\u2010RD) is an immune\u2010mediated disorder marked by fibro\u2010inflammatory masses that can infiltrate multiple organ systems. Due to its relatively recent discovery and limited understanding of its pathophysiology, IgG4\u2010related disease may be difficult to recognize and is consequently potentially underdiagnosed. Renal involvement is becoming regarded as one of the key features of this disease. To date, the most well\u2010recognized renal complication of IgG4\u2010related disease is tubulointerstitial nephritis, but membranous glomerulonephritis, renal masses, and retroperitoneal fibrosis have also been reported. This concise review has two objectives. First, it will briefly encapsulate the history, epidemiology, and presentation of IgG4\u2010related disease. Second, it will examine the reported renal manifestations of IgG4\u2010related disease, exploring the relevant histology, imaging, clinical features, and treatment considerations. This synthesis will be highly relevant for nephrologists, rheumatologists, general internists, and renal pathologists to raise awareness and help improve early recognition of IgG4\u2010related kidney disease (IgG4\u2010RKD).<\/jats:p>","DOI":"10.1155\/2024\/4421589","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T12:14:38Z","timestamp":1719231278000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Renal Manifestations of IgG4\u2010Related Disease: A Concise Review"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6213-3898","authenticated-orcid":false,"given":"Shahrukh T.","family":"Towheed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayel","family":"Zanjir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin Yi Mi","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0627-3929","authenticated-orcid":false,"given":"Jocelyn","family":"Garland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9457-3587","authenticated-orcid":false,"given":"Marie","family":"Clements-Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1104650"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1175-y"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200103083441005"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-006-0518-y"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2011.01.023"},{"key":"e_1_2_10_6_2","volume-title":"\u00dcber eine Eigenartige Symmetrische Erkrankung der Tr\u00e4nen und Mundspeicheldr\u00fcsen","author":"Mikulicz J.","year":"1892"},{"key":"e_1_2_10_7_2","first-page":"815","article-title":"\u00dcber entz\u00fcndliche tumoren der submaxill\u00e4r-speicheldr\u00fcse","volume":"15","author":"K\u00fcttner H.","year":"1896","journal-title":"Beitr Klin Chir"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20215"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0404"},{"key":"e_1_2_10_10_2","first-page":"101","article-title":"Die chronische zur bildung eisenharter tumoren fuehrende entzuendung der schilddruese","volume":"25","author":"Riedel B.","year":"1896","journal-title":"Verhandlungen der deutschen Gesellschaft f\u00fcr Chirurgie"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.16"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2020.104016"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2970"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.243"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2007.06.111"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2018.05.004"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.05.011"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000010935"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/bor.0b013e3283412f7c"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102694"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21700"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2012.02805.x"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-012-0521-y"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.5009\/gnl18085"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-015-1189-4"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/pgp.0000000000000293"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13296"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-014-0110-z"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.06.003"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2003.12.006"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg477"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-006-0478-2"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.5102"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.271"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10061329"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40697-016-0126-5"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.5414\/cnp71173"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213308.43929.97"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-016-0460-z"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9690218"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/md.0b013e318289610f"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185x.12863"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-011-0521-2"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-020-01993-7"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10165-011-0508-6"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/358371"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.08.013"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2011010062"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.183"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.236"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.14-6-s56"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0500-7"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtauto.2020.100047"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.72"},{"key":"e_1_2_10_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10165-011-0571-z"},{"key":"e_1_2_10_56_2","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2020.1859710"},{"key":"e_1_2_10_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.41120"},{"key":"e_1_2_10_58_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841851003738846"},{"key":"e_1_2_10_59_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.3787"},{"key":"e_1_2_10_60_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.10.025"},{"key":"e_1_2_10_61_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2017.02.001"},{"key":"e_1_2_10_62_2","doi-asserted-by":"crossref","first-page":"312","DOI":"10.4103\/0971-4065.114491","article-title":"Renal disease masquerading as pyrexia of unknown origin","volume":"23","author":"Korivi D.","year":"2013","journal-title":"Indian Journal of Nephrology"},{"key":"e_1_2_10_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.342"},{"key":"e_1_2_10_64_2","doi-asserted-by":"publisher","DOI":"10.1097\/mnh.0000000000000102"},{"key":"e_1_2_10_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.191"},{"key":"e_1_2_10_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.06.002"},{"key":"e_1_2_10_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.101"},{"key":"e_1_2_10_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.382"},{"key":"e_1_2_10_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.454"},{"key":"e_1_2_10_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/mr\/roac065"},{"key":"e_1_2_10_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.34593"},{"key":"e_1_2_10_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.32"},{"key":"e_1_2_10_73_2","doi-asserted-by":"publisher","DOI":"10.5414\/CN107768"},{"key":"e_1_2_10_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(97)04122-6"},{"key":"e_1_2_10_75_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa0810457"},{"key":"e_1_2_10_76_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.05.002"},{"key":"e_1_2_10_77_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.48.1339"},{"key":"e_1_2_10_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehpc.2019.200331"},{"key":"e_1_2_10_79_2","doi-asserted-by":"publisher","DOI":"10.5414\/cnp68308"},{"key":"e_1_2_10_80_2","doi-asserted-by":"publisher","DOI":"10.5414\/cn107114"},{"key":"e_1_2_10_81_2","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-7-5"},{"key":"e_1_2_10_82_2","article-title":"Systemic amyloidosis as a rare complication of IgG4 related disease: case report and literature review","author":"Mendonca L. O.","year":"2021","journal-title":"Research Square"},{"key":"e_1_2_10_83_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa467"},{"key":"e_1_2_10_84_2","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2015.1019958"},{"key":"e_1_2_10_85_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmc1614275"},{"key":"e_1_2_10_86_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-4-431-55687-9_13"},{"key":"e_1_2_10_87_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-008-0425-8"},{"key":"e_1_2_10_88_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-013-1421-5"},{"key":"e_1_2_10_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2018.05.019"},{"key":"e_1_2_10_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2013.01.004"},{"key":"e_1_2_10_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.11.056"},{"key":"e_1_2_10_92_2","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12769"},{"key":"e_1_2_10_93_2","doi-asserted-by":"publisher","DOI":"10.1159\/000495570"},{"key":"e_1_2_10_94_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez459"},{"key":"e_1_2_10_95_2","doi-asserted-by":"publisher","DOI":"10.24875\/cirue.m18000009"},{"key":"e_1_2_10_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2020.09.002"},{"key":"e_1_2_10_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eucr.2019.100844"},{"key":"e_1_2_10_98_2","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2012.13.6.803"},{"key":"e_1_2_10_99_2","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2012-201218"},{"key":"e_1_2_10_100_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-016-1599-z"},{"key":"e_1_2_10_101_2","doi-asserted-by":"publisher","DOI":"10.1007\/82_2016_36"},{"key":"e_1_2_10_102_2","doi-asserted-by":"publisher","DOI":"10.1097\/bor.0b013e328341a240"},{"key":"e_1_2_10_103_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39132"},{"key":"e_1_2_10_104_2","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000004002"},{"key":"e_1_2_10_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2018.08.011"},{"key":"e_1_2_10_106_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.27435"},{"key":"e_1_2_10_107_2","doi-asserted-by":"publisher","DOI":"10.1097\/md.0b013e3182431ef6"}],"container-title":["International Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2024\/4421589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T12:14:46Z","timestamp":1719231286000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2024\/4421589"}},"subtitle":[],"editor":[{"given":"Emmanuel","family":"Effa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":107,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/2024\/4421589"],"URL":"https:\/\/doi.org\/10.1155\/2024\/4421589","archive":["Portico"],"relation":{},"ISSN":["2090-214X","2090-2158"],"issn-type":[{"value":"2090-214X","type":"print"},{"value":"2090-2158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4421589"}}