{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:01:59Z","timestamp":1785445319218,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":120,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Goettingen University"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Dentistry"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Medication\u2010related osteonecrosis of the jaw (MRONJ) is a rare, serious, and debilitating disease of unknown cause that can be associated with significant health\u2010related quality of life (HRQOL) impairment. Hematological disease is characterized by a nonhealing exposed jawbone in patients with a history of antiresorptive or antiangiogenic agent use without radiation exposure to the head or neck.\n                    <jats:italic>Patients and Materials and Methods<\/jats:italic>\n                    . This prospective study over the period from May 2020 to December 2021 included a representative sample consisting of 27 patients with at least stage 2 MRONJ lesions who underwent surgical rehabilitation via oral and maxillofacial surgery at the University Medical Center G\u00f6ttingen, Germany. Quality of life data were collected over a 6\u2010month postoperative period using the Health\u2010Related QOL (SF\u201012) and Oral Health\u2010Related QOL (OHIP\u201014) questionnaires.\n                    <jats:italic>Results<\/jats:italic>\n                    . A total of 27 patients considered in the study had a total of 42 MRONJ lesions, corresponding to a mean of 1.56\u2009necroses per patient. MRONJ lesions were downstaged in 85% of the patients. HRQOL was evaluated with the SF\u201012 questionnaire. Significant improvements were found in six of the eight categories (General Health (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009 &lt; 0.001), Bodily Pain (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001), Mental Health (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001), Vitality (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009 &lt; 0.001), Role\u2010Emotional (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.028), and Social Functioning (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.031)). The OHRQOL score also improved significantly after surgical intervention (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . With completed surgical therapy, improvements in HRQOL and OHRQOL are measurable.\n                  <\/jats:p>","DOI":"10.1155\/2024\/4435791","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T21:05:08Z","timestamp":1714511108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Improvement of Quality of Life after Surgical Treatment of Patients with MRONJ: A Prospective Analysis Using the SF\u201012 and OHIP\u201014 Questionnaires"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1025-6758","authenticated-orcid":false,"given":"Georg","family":"Hoene","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4069-8023","authenticated-orcid":false,"given":"Nikolaus","family":"von Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3506-5942","authenticated-orcid":false,"given":"Denise","family":"Sievers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0306-3722","authenticated-orcid":false,"given":"Lukas","family":"Schuffelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4134-2301","authenticated-orcid":false,"given":"Susanne","family":"Wolfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5790-8349","authenticated-orcid":false,"given":"Kathi","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8520-9481","authenticated-orcid":false,"given":"Boris","family":"Schminke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3694-2828","authenticated-orcid":false,"given":"Phillipp","family":"Brockmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1757-9165","authenticated-orcid":false,"given":"Philipp","family":"Kauffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8093293"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.04.031"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.01.009"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1051\/mbcb\/2012049"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells11244097"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10194367"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.01.006"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080205"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2004.02.004"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010009\u20100688\u20101"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2010\u20100183"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.2768"},{"key":"e_1_2_11_13_2","first-page":"3","article-title":"Development and evaluation of the oral health impact profile","volume":"11","author":"Slade G. 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