{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:26:01Z","timestamp":1791059161353,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":301,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100078"],"award-info":[{"award-number":["82100078"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["2021xkj159"],"award-info":[{"award-number":["2021xkj159"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["2023xkj208"],"award-info":[{"award-number":["2023xkj208"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2023AH030117"],"award-info":[{"award-number":["2023AH030117"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Vitamin D deficiency elevates the risk of chronic obstructive pulmonary disease (COPD) patients. Iron parameters elevation and glutathione peroxidase 4 (GPX4) reduction are involved in the process of COPD. The goal is to explore the associations of vitamin D with GPX4 and iron parameters in COPD patients through a case\u2013control study.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> COPD patients and control subjects were enrolled. Serum samples and lung tissues were collected. Serum vitamin D and iron levels and pulmonary ferritin and GPX4 expressions were determined. In addition, human pulmonary epithelial cells (BEAS\u20102B) were incubated with 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> (100\u2009nM), the active form of vitamin D3. Then, vitamin D receptor (VDR) and nuclear factor (erythroid\u2010derived 2)\u2010like 2 (Nrf\u20102) signaling were detected.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> In patients with COPD, serum 25\u2010hydroxyvitamin D (25(OH)D) decreased, and iron and ferritin levels in serum and lung tissues increased. Furthermore, pulmonary expression of GPX4 was reduced. Correlative analyzes indicated that lung function was inversely correlated with iron parameters and positively correlated with GPX4. The results showed that serum 25(OH)D deficiency was associated with an elevation in serum iron parameters and a reduction in pulmonary GPX4. In addition, VDR\u2010 and Nrf\u20102\u2010positive lung nuclei were decreased in COPD patients than in control subjects. In patients with COPD, the results indicated a positive relationship between VDR and Nrf\u20102. Further analysis revealed that Nrf\u20102\u2010positive nuclei were negatively correlated with iron parameters. <jats:italic>In vitro<\/jats:italic> experiments found that 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> treatment activated VDR signaling and elevated the expression of Nrf\u20102 and GPX4 in BEAS\u20102B cells.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Vitamin D deficiency is positively associated with GPX4 reduction and iron parameters elevation in COPD patients. It is recommended to explore the role of vitamin D supplementation in the progression of COPD.<\/jats:p>","DOI":"10.1155\/2024\/4505905","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T07:50:45Z","timestamp":1730101845000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Associations of Vitamin D With GPX4 and Iron Parameters in Chronic Obstructive Pulmonary Disease Patients: A Case\u2013Control Study"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0504-4534","authenticated-orcid":false,"given":"Jun","family":"Fei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8191-0907","authenticated-orcid":false,"given":"Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5518-4247","authenticated-orcid":false,"given":"Jia-Fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7262-6163","authenticated-orcid":false,"given":"Qiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0424-6601","authenticated-orcid":false,"given":"Yu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0889-892X","authenticated-orcid":false,"given":"Ting-Dong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1069-3560","authenticated-orcid":false,"given":"Lin","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"e_1_2_15_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(17)31222-9"},{"key":"e_1_2_15_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/aitc202008040"},{"key":"e_1_2_15_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-3-201108020-00008"},{"key":"e_1_2_15_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-2600(20)30105-3"},{"key":"e_1_2_15_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(22)00470-6"},{"key":"e_1_2_15_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12660"},{"key":"e_1_2_15_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(06)68516-4"},{"key":"e_1_2_15_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2012.03.007"},{"key":"e_1_2_15_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112164"},{"key":"e_1_2_15_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.4.1080s"},{"key":"e_1_2_15_11_2","doi-asserted-by":"publisher","DOI":"10.5582\/ddt.2015.01002"},{"key":"e_1_2_15_12_2","doi-asserted-by":"publisher","DOI":"10.2147\/copd.s101382"},{"key":"e_1_2_15_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900229"},{"key":"e_1_2_15_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000964"},{"key":"e_1_2_15_15_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.58452"},{"key":"e_1_2_15_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi300752r"},{"key":"e_1_2_15_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00450.2005"},{"key":"e_1_2_15_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1670"},{"key":"e_1_2_15_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2008.11.004"},{"key":"e_1_2_15_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2021.104645"},{"key":"e_1_2_15_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2018.02.010"},{"key":"e_1_2_15_22_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7342"},{"key":"e_1_2_15_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.624529"},{"key":"e_1_2_15_24_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7176"},{"key":"e_1_2_15_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10991-7"},{"key":"e_1_2_15_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2018.12.007"},{"key":"e_1_2_15_27_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.751206"},{"key":"e_1_2_15_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67047-w"},{"key":"e_1_2_15_29_2","doi-asserted-by":"publisher","DOI":"10.2147\/copd.s116982"},{"key":"e_1_2_15_30_2","doi-asserted-by":"publisher","DOI":"10.2147\/copd.s340113"},{"key":"e_1_2_15_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102203"},{"key":"e_1_2_15_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2256-z"},{"key":"e_1_2_15_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.114548"},{"key":"e_1_2_15_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apr.2021.101275"},{"key":"e_1_2_15_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-020-00376-9"},{"key":"e_1_2_15_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-021-00507-w"},{"key":"e_1_2_15_37_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.7.581"},{"key":"e_1_2_15_38_2","doi-asserted-by":"publisher","DOI":"10.2147\/copd.s228307"},{"key":"e_1_2_15_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12970"},{"key":"e_1_2_15_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-024-00702-5"},{"key":"e_1_2_15_41_2","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2024.2326021"},{"key":"e_1_2_15_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ensci.2021.100379"},{"key":"e_1_2_15_43_2","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2023.2189908"},{"key":"e_1_2_15_44_2","first-page":"179","article-title":"Interleukin-6 as Diagnostic Marker for Neonatal Sepsis: Determination of Access IL-6 Cutoff for Newborns","volume":"54","author":"Prinsen J. H.","year":"2008","journal-title":"Clinical Laboratory"},{"key":"e_1_2_15_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.11.035"},{"key":"e_1_2_15_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.11.005"},{"key":"e_1_2_15_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111537"},{"key":"e_1_2_15_48_2","doi-asserted-by":"publisher","DOI":"10.22038\/ijbms.2021.56908.12695"},{"key":"e_1_2_15_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.01.052"},{"key":"e_1_2_15_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21944-3"},{"key":"e_1_2_15_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-022-01637-4"},{"key":"e_1_2_15_52_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m210664200"},{"key":"e_1_2_15_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1536-9"},{"key":"e_1_2_15_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2014.02.002"},{"key":"e_1_2_15_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2017.65"},{"key":"e_1_2_15_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101107"},{"key":"e_1_2_15_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12951"},{"key":"e_1_2_15_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.101093"},{"key":"e_1_2_15_59_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.116.239475"},{"key":"e_1_2_15_60_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu5104022"},{"key":"e_1_2_15_61_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3mt00347g"},{"key":"e_1_2_15_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2022.04.006"},{"key":"e_1_2_15_63_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-015-0271-x"},{"key":"e_1_2_15_64_2","doi-asserted-by":"publisher","DOI":"10.1515\/med-2019-0096"},{"key":"e_1_2_15_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.11.013"},{"key":"e_1_2_15_66_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242015315"}],"updated-by":[{"DOI":"10.1155\/carj\/9879624","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000}}],"container-title":["Canadian Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2024\/4505905","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T07:50:50Z","timestamp":1730101850000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2024\/4505905"}},"subtitle":[],"editor":[{"given":"Xin","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/2024\/4505905"],"URL":"https:\/\/doi.org\/10.1155\/2024\/4505905","archive":["Portico"],"relation":{},"ISSN":["1198-2241","1916-7245"],"issn-type":[{"value":"1198-2241","type":"print"},{"value":"1916-7245","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-10-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4505905"}}