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Two-sample Mendelian randomization (MR) was conducted to assess the causal relationship between angina pectoris and gout. Material and Methods. Based on genome-wide association studies, single nucleotide polymorphisms (SNPs) that were closely associated with gout were selected from the UK Biobank\u2013Neale Lab (ukb-a-107) as genetic instrumental variables. Considering that gout is characterized by elevated blood uric acid levels, SNPs related to blood uric acid levels were screened from BioBank Japan (bbj-a-57) as auxiliary gene instrumental variables. SNPs closely associated with angina pectoris onset were screened from the FINN dataset (finn-b-I9_ANGINA) as outcome variables. Two-sample MR was conducted, with inverse variance weighting (IVW) of the random effects model as the primary result, along with the weighted median method (WME) and the MR-Egger regression method. To further confirm the causal relationship between angina and gout incidence, a meta-analysis was conducted on the IVW results of the ukb-a-107 and bbj-a-57. Results. The odds ratios and 95% confidence intervals of the IVW, WME, and MR-Egger results of ukb-a-107 were (OR\u2009=\u200933.72; 95% CI: 2.07\u223c550.38), (OR\u2009=\u200957.94; 95% CI: 2.75\u223c1219.82), and (OR\u2009=\u200996.38; 95% CI: 0.6\u223c15556.93), respectively. The <jats:inline-formula><a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><a:mi>P<\/a:mi><\/a:math><\/jats:inline-formula> values of IVW and WME were 0.014 and 0.014 (both &lt;0.05), respectively, indicating that the development of angina pectoris was significantly associated with the incidence of gout. The odds ratios and 95% confidence intervals of the IVW, WME, and MR-Egger about bbj-a-57 were (OR\u2009=\u20091.20; 95% CI: 1.07\u223c1.34), (OR\u2009=\u20091.19; 95% CI: 1.02\u223c1.38), and (OR\u2009=\u20091.30; 95% CI; 1.06\u223c1.60), respectively. The <jats:inline-formula><c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><c:mi>P<\/c:mi><\/c:math><\/jats:inline-formula> values of IVW, WME and MR-Egger were 0.001, 0.027 and 0.017 (all &lt;0.05), respectively, indicating a significant correlation between angina and blood uric acid levels. Scatter plots of ukb-a-107 and bbj-a-57 showed that the causal association estimates of the IVW, MR-Egger, and weighted median methods were similar and that the MR results were accurate. Funnel plots and the MR-Egger intercept of ukb-a-107 and bbj-a-57 showed the absence of horizontal pleiotropy. The leave-out sensitivity analysis results of ukb-a-107 and bbj-a-57 are stable. The meta-analysis of IVW results for ukb-a-107 and bbj-a-57 showed (OR\u2009=\u20091.20; 95% CI: 1.07\u20131.34, <jats:inline-formula><e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><e:mi>P<\/e:mi><e:mo>=<\/e:mo><e:mn>0.02<\/e:mn><\/e:math><\/jats:inline-formula>), confirming that gout characterized by high blood uric acid levels significantly increases the risk of angina attacks. Conclusions. This MR study found a clear causal relationship between angina pectoris and gout, which increases the risk of angina pectoris.<\/jats:p>","DOI":"10.1155\/2024\/4564596","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:35:07Z","timestamp":1712709307000},"page":"1-11","source":"Crossref","is-referenced-by-count":4,"title":["The Causal Relationship between Angina Pectoris and Gout Based on Two Sample Mendelian Randomization"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8346-178X","authenticated-orcid":true,"given":"Jian","family":"Xiong","sequence":"first","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2524-7099","authenticated-orcid":true,"given":"Yuxin","family":"Sun","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0370-7795","authenticated-orcid":true,"given":"Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi 530001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6159-3776","authenticated-orcid":true,"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6030-9160","authenticated-orcid":true,"given":"Fayang","family":"Ling","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9192-2329","authenticated-orcid":true,"given":"Yin","family":"Wei","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5489-7034","authenticated-orcid":true,"given":"Qianhua","family":"Zheng","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3294-8870","authenticated-orcid":true,"given":"Wenchuan","family":"Qi","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8518-9268","authenticated-orcid":true,"given":"Fanrong","family":"Liang","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2019.08.001"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.11390"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20065"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2018.06.011"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000028850"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2022.01.007"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket293"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000350"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.91"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(18)32203-7"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.121231"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(86)92972-7"},{"issue":"10","key":"13","first-page":"1227","article-title":"Mendelian randomization: the basic principles, methods and limitations","volume":"21","author":"T. 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