{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T14:31:12Z","timestamp":1763649072137,"version":"3.45.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T00:00:00Z","timestamp":1727568000000},"content-version":"vor","delay-in-days":272,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Critical Care"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    Cerebral malaria is the most severe complication of\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    infection. Left untreated, it is universally fatal. Coma is the clinical hallmark, emerging between the first and third days of fever. Adults typically present with mild cerebral edema, usually with a more favorable prognosis compared to the pediatric population. We present a case of a 48\u2010year\u2010old man with a recent travel to Angola who presented comatose on the second day of a febrile illness with clinical signs of cerebral herniation and diffuse cerebral edema and cerebellar tonsil ectopia on cranioencephalic computed tomography. He had a missed diagnosis on a first visit to the emergency department 2 days prior. The diagnosis of cerebral malaria was confirmed after the identification of the parasite in peripheral blood. He was admitted to an intensive care unit; however, progression to brain death was inevitable within a few hours. Malaria affects 5% of the world\u2019s population. In Portugal, it has an incidence of 0.01 in every 1000 inhabitants, and all cases are imported. Despite its rarity in a nonendemic country, its severity alerts to the consideration of this syndrome in the etiologic workup of coma. The early recognition of the diagnosis is of major importance for the establishment of definitive treatment, as its timely administration has a crucial impact on the outcome.\n                  <\/jats:p>","DOI":"10.1155\/2024\/4621985","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T02:05:58Z","timestamp":1727661958000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sudden Onset of Coma and Fulminant Progression to Brain Death in a 48\u2010Year\u2010Old Male With Cerebral Malaria"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5612-0966","authenticated-orcid":false,"given":"Marina","family":"Costa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4313-4582","authenticated-orcid":false,"given":"Cristiana","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8158-4586","authenticated-orcid":false,"given":"Mauro","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5475-5845","authenticated-orcid":false,"given":"Lu\u00eds","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4451-7637","authenticated-orcid":false,"given":"Pedro","family":"Silveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,29]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.12313_2"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-13-177"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181eee738"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1179\/135100001101536238"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/589287"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70247-7"},{"key":"e_1_2_10_7_2","first-page":"385","article-title":"Human cerebral malaria. A quantitative ultrastructural analysis of parasitized erythrocyte sequestration","volume":"119","author":"MacPherson G. G.","year":"1985","journal-title":"The American Journal of Pathology"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1647"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/89.5.351"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-267"},{"volume-title":"World malaria report 2022","year":"2022","author":"World Health Organization","key":"e_1_2_10_11_2"},{"key":"e_1_2_10_12_2","unstructured":"Instituto nacional de estat\u00edstica Taxa de incid\u00eancia da mal\u00e1ria por 1000 habitantes 2018 January 2024 https:\/\/www.ine.pt\/xportal\/xmain?xpid=INE%26xpgid=ine_indicadores%26indOcorrCod=0009672%26contexto=bd%26selTab=tab2."},{"key":"e_1_2_10_13_2","first-page":"24","article-title":"Mal\u00e1ria: estudo retrospetivo de casos cl\u00ednicos suspeitos de infe\u00e7\u00e3o por Plasmodium sp.(2010-2020)","volume":"10","author":"Reis T.","year":"2021","journal-title":"Boletim Epidemiol\u00f3gico Observa\u00e7\u00f5es"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1203.050736"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61924-1"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir405"}],"container-title":["Case Reports in Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2024\/4621985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T14:26:22Z","timestamp":1763648782000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2024\/4621985"}},"subtitle":[],"editor":[{"given":"Mehmet","family":"Doganay","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/2024\/4621985"],"URL":"https:\/\/doi.org\/10.1155\/2024\/4621985","archive":["Portico"],"relation":{},"ISSN":["2090-6420","2090-6439"],"issn-type":[{"type":"print","value":"2090-6420"},{"type":"electronic","value":"2090-6439"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2024-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4621985"}}