{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:27:50Z","timestamp":1786372070316,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":226,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Genomics"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Inflammatory myofibroblastic tumor (IMT) is a rare soft tissue tumor primarily occurring in the abdominopelvic region of young patients, and it is characterized by spindle\u2010shaped myofibroblasts, or fibroblasts surrounded by inflammatory infiltrate. Herein, we report a case of a 24\u2010year\u2010old male with a firm submucosal mass in the anterior right vocal fold diagnosed as an IMT that recurred 14 months later. The tumor demonstrated a novel THBS1::ALK fusion containing Exons 1\u20137 of the thrombospondin 1 (<jats:italic>THBS1<\/jats:italic>) gene fused to Exon 19 of the anaplastic lymphoma kinase (<jats:italic>ALK<\/jats:italic>) gene via next\u2010generation sequencing with the NextSeq sequencer. The fusion of <jats:italic>THBS1<\/jats:italic> to <jats:italic>ALK<\/jats:italic> potentially results in increased expression and constitutive activation of the ALK kinase domain. These findings not only broaden the repertoire of known <jats:italic>ALK<\/jats:italic> fusion partners implicated in tumorigenesis but also provide a novel avenue for investigating the etiology of recurrent IMT by considering this fusion event as a causal factor. To our knowledge, this is the second case of IMT of the larynx with this novel mutation reported in the literature and the first such case with a detailed description of this specific fusion and clinical recurrence.<\/jats:p>","DOI":"10.1155\/2024\/4937501","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T11:34:06Z","timestamp":1723635246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Recurrent Inflammatory Myofibroblastic Tumor of Larynx Harboring a Novel THBS1::ALK Fusion"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3016-3102","authenticated-orcid":false,"given":"Namra","family":"Ajmal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey M.","family":"Gargano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ujwala","family":"Gosavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madalina","family":"Tuluc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,14]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1177\/01455613221101087"},{"key":"e_1_2_9_2_2","series-title":"WHO classification of tumours series, 5th ed","volume-title":"WHO Classification of Tumours Editorial Board. 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