{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T21:26:47Z","timestamp":1781299607874,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":176,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Tropical Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Neglected tropical diseases (NTDs) are a heterogeneous group of medical conditions that commonly occur in underprivileged populations. NTDs are primarily diagnosed in tropical areas. Although South Africa is not situated in a tropical region, the high poverty rate makes the country susceptible to some NTDs. Limited data are available on the burden of NTDs in the Free State province of South Africa. This study aimed to determine the number of NTDs diagnosed on histopathological specimens in the public sector of the Free State province over a six\u2010year period and to evaluate the patient demographics. <jats:italic>Methods<\/jats:italic>. A retrospective, descriptive study was performed. All NTDs diagnosed in histopathological specimens from public sector hospitals in the province submitted to the Department of Anatomical Pathology, National Health Laboratory Service, and University of the Free State between 1 January 2015 and 31 December 2020 were included in the study. The demographic information, biopsy site, and referring hospital were noted for each case identified. <jats:italic>Results<\/jats:italic>. A total of 72 NTDs were diagnosed. The five most common diagnoses were echinococcosis (<jats:italic>n<\/jats:italic>\u2009=\u200933; 45.8%), bilharzia (<jats:italic>n<\/jats:italic>\u2009=\u200913; 18.1%), leprosy (<jats:italic>n<\/jats:italic>\u2009=\u20099; 12.5%), mycetoma (<jats:italic>n<\/jats:italic>\u2009=\u20098; 11.1%), and intestinal worms (<jats:italic>n<\/jats:italic>\u2009=\u20095; 6.9%). Ten (30.3%) patients diagnosed with echinococcosis came from the Free State\u2019s neighbouring country, Lesotho. <jats:italic>Conclusion<\/jats:italic>. Echinococcosis was the most prevalent NTD diagnosed in central South Africa. We recommend that the South African Department of Health add echinococcosis to the principal NTDs of significance in South Africa, alongside soil\u2010transmitted helminths, schistosomiasis, leprosy, and rabies.<\/jats:p>","DOI":"10.1155\/2024\/5076288","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T09:18:04Z","timestamp":1719307084000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Retrospective Review of Neglected Tropical Diseases Diagnosed on Histopathological Specimens in the Free State Province, South Africa, 2015\u20132020"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6394-0919","authenticated-orcid":false,"given":"Danita Linda","family":"le Grange","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3644-0342","authenticated-orcid":false,"given":"She\u2019neze Fatima","family":"Pillay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4284-1866","authenticated-orcid":false,"given":"Liska","family":"Budding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-2957","authenticated-orcid":false,"given":"Cornel","family":"van Rooyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7766-4062","authenticated-orcid":false,"given":"Jacqueline","family":"Goedhals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(19)33070-3"},{"key":"e_1_2_12_2_2","article-title":"Accelerating elimination of NTDs \u2013 towards 2030","author":"World Health Organization (WHO)","journal-title":"Expanded Special Project for Elimination of Neglected Tropical Diseases (ESPEN)"},{"key":"e_1_2_12_3_2","unstructured":"World Health Organization (WHO) Neglected tropical diseases https:\/\/www.who.int\/health-topics\/neglected-tropical-diseases#tab=tab_1."},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008001"},{"key":"e_1_2_12_5_2","unstructured":"South African Department of Health South Africa national master plan for the elimination of neglected tropical diseases (2019\u20132025) 2018."},{"key":"e_1_2_12_6_2","unstructured":"World Health Organization (WHO) Crossing the Billion. 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