{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:39:07Z","timestamp":1756312747612,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T00:00:00Z","timestamp":1726876800000},"content-version":"vor","delay-in-days":264,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:bold>Aims:<\/jats:bold> This study was aimed at assessing the association of oral glucose tolerance test (OGTT) glucose threshold levels and the requirement of insulin therapy in twin pregnancies with gestational diabetes mellitus (GDM).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> In this post hoc analysis of a cohort study spanning 18 years, 446 patients with twin pregnancy and GDM (246 managed with lifestyle modification and 200 requiring pharmacotherapy) were included. We collected and evaluated maternal characteristics, as well as fasting, 1\u2010h, and 2\u2010h glucose concentrations from a standardized 75\u2010g OGTT. The assessment methods included logistic regression analysis, positive and negative predictive values, area under the curve (AUC), and random forest analysis.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The fasting (<jats:italic>p<\/jats:italic> &lt; 0.01, OR: 1.03 [95% CI 1.01\u20131.05]) and 1\u2010h (<jats:italic>p<\/jats:italic> &lt; 0.01; OR: 1.01 [95% CI 1.00\u20131.02]) glucose levels during the OGTT were significantly associated with the subsequent need for insulin therapy, with thresholds of 95\u2009mg\/dL for fasting glucose and 184\u2009mg\/dL for the 1\u2010h OGTT. Additionally, indications for insulin therapy were marked by thresholds of 108\u2009mg\/dL at G0, 215\u2009mg\/dL at G60, and 86\u2009mg\/dL at G120.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Identifying threshold values for insulin therapy and risk stratification in twin pregnancy are crucial for optimal patient management.<\/jats:p>","DOI":"10.1155\/2024\/5203116","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T11:06:13Z","timestamp":1726916773000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Risk Stratification in Twin Pregnancies Complicated by GDM"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1065-5313","authenticated-orcid":false,"given":"Anja","family":"Catic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0523-5696","authenticated-orcid":false,"given":"Florian","family":"Heinzl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3922-7443","authenticated-orcid":false,"given":"Christian","family":"G\u00f6bl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9214-740X","authenticated-orcid":false,"given":"G\u00fclen","family":"Yerlikaya-Schatten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4021-1262","authenticated-orcid":false,"given":"Theresa","family":"Reischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,21]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70324-8"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802663194"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2016-0186"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-018-4847-9"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-003-0483-z"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2586"},{"key":"e_1_2_12_7_2","unstructured":"World Health Organization Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy January 2024 https:\/\/apps.who.int\/iris\/handle\/10665\/85975."},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1848"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042973"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2021-0247"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-4047-8"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0499"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2011.01329.x"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2007.0667"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3243754"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4858976"},{"key":"e_1_2_12_17_2","first-page":"283","article-title":"Using the 100-g oral glucose tolerance test to predict fetal and maternal outcomes in women with gestational diabetes mellitus","volume":"32","author":"Lin C. 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