{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:38:28Z","timestamp":1753886308661,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":254,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Infectious mononucleosis (IM), caused by the Epstein\u2013Barr virus (EBV), typically presents with fever, tonsillopharyngitis, and lymphadenopathy while rare, renal, and hematological complications such as gross hematuria and hemolytic anemia can occur, particularly in children. <jats:italic>Case Presentation<\/jats:italic>. We describe a 15\u2010year\u2010old male with infectious mononucleosis presenting with abdominal pain, sore throat, and red\u2010colored urine for three days. Laboratory findings revealed leukocytosis, elevated liver enzymes, and hemoglobinuria. Serological testing confirmed EBV infection. Despite intravascular hemolysis, the patient\u2019s anemia was mild, and he responded well to supportive care. <jats:italic>Discussion<\/jats:italic>. Gross hematuria and hemolytic anemia are uncommon in IM, with limited reports. Proposed mechanisms include viral\u2010induced renal injury and autoimmune hemolysis. Differential diagnosis should consider other causes of hematuria, which can be differentiated through urine microscopy and serological tests. IM should be considered in patients with pharyngitis and hematuria, especially when other causes are excluded.<\/jats:p>","DOI":"10.1155\/2024\/5236969","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T05:52:27Z","timestamp":1726120347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gross Hematuria and Hemolytic Anemia in Infectious Mononucleosis"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8261-832X","authenticated-orcid":false,"given":"Chinmayi","family":"Sharma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navneet","family":"Venugopal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3874-4819","authenticated-orcid":false,"given":"Shivaiah","family":"Balachandra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0070(88)90024-1"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1955.02950330046008a"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1966.03100130127041"},{"key":"e_1_2_8_4_2","first-page":"89","article-title":"Infectious mononucleosis with hepatic and renal involvement","volume":"7","author":"Brun C.","year":"1970","journal-title":"Scandinavian Journal of Gastroenterology-Supplement"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1965.03090250060025"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-33-5-1274"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.3143.452"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.75.6.1003"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0272-6386(98)70134-9"},{"key":"e_1_2_8_10_2","first-page":"857","article-title":"Intense jaundice in infectious mononucleosis","volume":"48","author":"Madigan N. P.","year":"1973","journal-title":"Mayo Clinic Proceedings"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1960.00270130124016"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992286900800310"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0197-0070(86)80039-0"}],"container-title":["Case Reports in Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2024\/5236969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T05:52:31Z","timestamp":1726120351000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2024\/5236969"}},"subtitle":[],"editor":[{"given":"Junji","family":"Takaya","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/2024\/5236969"],"URL":"https:\/\/doi.org\/10.1155\/2024\/5236969","archive":["Portico"],"relation":{},"ISSN":["2090-6803","2090-6811"],"issn-type":[{"type":"print","value":"2090-6803"},{"type":"electronic","value":"2090-6811"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2024-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5236969"}}