{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:52:47Z","timestamp":1790124767549,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2024,1,24]]},"abstract":"<jats:p>\n                    Endometriosis (EM) is a gynecological disorder that causes morbidity in women and is characterized by endometrial tissue in the uterus cavity. This study investigated the mechanism of genistein in the VEGF-A and ER-\u03b1 expression through in vivo and in silico approaches. An in vivo study was conducted by thirty-six mice that were divided into six groups including control, EM, and EM treatment with genistein with the doses of 1.3, 1.95, 2.6, and 3.25\u2009mg\/day for 14\u2009days. Peritoneal tissues with lesions were collected and analyzed by immunohistochemistry to measure the VEGF-A and ER-\u03b1 expression. The data were analyzed using a statistical approach using one-way ANOVA followed by Tukey HSD test with a significant value\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    . In silico study was conducted for investigating the inhibition mechanism of genistein in VEGF-A and ER-\u03b1 protein. Genistein significantly reduced the VEGF-A and ER-\u03b1 expression with the optimum dose of 3.25\u2009mg\/day. Molecular docking showed that genistein inhibited VEGF-A in several active site residues of VEGF-A, also blocked the ER-\u03b1 protein in estradiol binding sites. This study concluded that genistein prevented endometriosis by performing the antiangiogenic activity and showed a similar function to estradiol.\n                  <\/jats:p>","DOI":"10.1155\/2024\/5338212","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T18:20:12Z","timestamp":1706120412000},"page":"1-7","source":"Crossref","is-referenced-by-count":12,"title":["Genistein Ameliorated Vascular Endothelial Growth Factor-A (VEGF-A) and Estrogen Receptor-Alpha (ER-\u03b1) in Endometriosis Mice Model, In Vivo and In Silico"],"prefix":"10.1155","volume":"2024","author":[{"given":"Sutrisno","family":"Sutrisno","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, University of Brawijaya, Saiful Anwar General Hospital, Malang, East Java, Indonesia"},{"name":"Magister of Midwifery, Faculty of Medicine, University of Brawijaya, Malang, East Java, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5021-1274","authenticated-orcid":true,"given":"Maharani","family":"Maharani","sequence":"additional","affiliation":[{"name":"Department of Midwifery, Polytechnic of Health-Ministry of Health, Aceh, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.714790"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i4.1243"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21082815"},{"issue":"1","key":"4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/09513590601010474","article-title":"The way forward","volume":"23","author":"P. 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Sutrisno","year":"2019","journal-title":"Drug Invention Today"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.55241\/spibio.v2i2.47"},{"key":"19","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/978-1-4939-9752-7_10","article-title":"WFJ. de Azevedo Molegro virtual docker for docking","volume":"2053","author":"G. Bitencourt-Ferreira","year":"2019","journal-title":"Methods in Molecular Biology"},{"issue":"1","key":"20","first-page":"15","article-title":"Anti-apoptotic activity of anthocyanins has potential to inhibit caspase-3 signaling","volume":"10","author":"D. R. T. Sari","year":"2021","journal-title":"Journal of Tropical Life Science"},{"key":"21","article-title":"Genistein: an integrative overview of its mode of action, pharmacological properties, and Health benefits","volume":"7","author":"J. Sharifi-Rad","year":"2021","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01336"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2017.03.002"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.33024\/jkm.v8i1.5847"},{"issue":"4","key":"25","first-page":"195","article-title":"Capsaicinoids from capsicum annuum as an alternative FabH inhibitor of Mycobacterium tuberculosis: in silico study capsaicinoids from capsicum annuum as an alternative FabH inhibitor of Mycobacterium tuberculosis: in silico study","volume":"25","author":"G. C. Krisnamurti","year":"2019","journal-title":"Makara Journal of Science"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1088\/1742-6596\/1665\/1\/012024"}],"container-title":["The Scientific World Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2024\/5338212.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2024\/5338212.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2024\/5338212.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T18:20:21Z","timestamp":1706120421000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/tswj\/2024\/5338212\/"}},"subtitle":[],"editor":[{"given":"Mohd Sajid","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,1,24]]},"references-count":26,"alternative-id":["5338212","5338212"],"URL":"https:\/\/doi.org\/10.1155\/2024\/5338212","relation":{},"ISSN":["1537-744X","2356-6140"],"issn-type":[{"value":"1537-744X","type":"electronic"},{"value":"2356-6140","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1,24]]}}}