{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:08:59Z","timestamp":1773248939554,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2024,2,23]]},"abstract":"<jats:p>Purpose. Ovarian cancer in the early stage requires a complete surgical staging, including radical lymphadenectomy, implying subsequent risk of morbidity and complications. Sentinel lymph node (SLN) mapping is a procedure that attempts to reduce radical lymphadenectomy-related complications and morbidities. Our study evaluates the feasibility of SLN mapping in patients with ovarian tumors by the use of intraoperative Technetium-99m-Phytate (Tc-99m-Phytate) and postoperative lymphoscintigraphy using tomographic (single-photon emission computed tomography\/computed tomography (SPECT\/CT)) acquisition. Materials and Methods. Thirty-two patients with ovarian mass participated in this study. Intraoperative injection of the radiopharmaceutical was performed just after laparotomy and before the removal of tumor in utero-ovarian and suspensory ligaments of the ovary just beneath the peritoneum. Subsequently, pelvic and para-aortic lymphadenectomy was performed for malignant masses, and the presence of tumor in the lymph nodes was assessed through histopathological examination. Conversely, lymphadenectomy was not performed in patients with benign lesions or borderline ovarian tumors. Lymphoscintigraphy was performed within 24\u2009hr using tomographic acquisition (SPECT\/CT) of the abdomen and pelvis. Results. Final pathological examination showed 19 patients with benign pathology, 5 with borderline tumors, and 6 with malignant ovarian tumors. SPECT\/CT identified SLNs in para-aortic-only areas in 6 (20%), pelvic\/para-aortic areas in 14 (47%), and pelvic-only areas in 7 (23%) cases. Notably, additional unusual SLN locations were revealed in perirenal, intergluteal, and posterior to psoas muscle regions in three patients. We were not able to calculate the false negative rate due to the absence of patients with involved lymph nodes. Conclusion. SLN mapping using intraoperative injection of radiotracers is safe and feasible. Larger studies with more malignant cases are needed to better evaluate the sensitivity of this method for lymphatic staging of ovarian malignancies.<\/jats:p>","DOI":"10.1155\/2024\/5453692","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T22:50:08Z","timestamp":1708728608000},"page":"1-9","source":"Crossref","is-referenced-by-count":8,"title":["Sentinel Node Mapping in Ovarian Tumors: A Study Using Lymphoscintigraphy and SPECT\/CT"],"prefix":"10.1155","volume":"2024","author":[{"given":"Saeideh","family":"Ataei Nakhaei","sequence":"first","affiliation":[{"name":"Nuclear Medicine Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramin","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayyed Mostafa","family":"Mostafavi","sequence":"additional","affiliation":[{"name":"Department of Computer Engineering, University of Isfahan, Isfahan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9808-780X","authenticated-orcid":true,"given":"Giorgio","family":"Treglia","sequence":"additional","affiliation":[{"name":"Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland"},{"name":"Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana, Lugano, Switzerland"},{"name":"Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malihe","family":"Hassanzadeh","sequence":"additional","affiliation":[{"name":"Women\u2019s Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Esmaeilpour","sequence":"additional","affiliation":[{"name":"Women\u2019s Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Negar Sadat","family":"Taheri","sequence":"additional","affiliation":[{"name":"Women\u2019s Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjaneh","family":"Farazestanian","sequence":"additional","affiliation":[{"name":"Women\u2019s Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3413\/nukmed-0339-10-07"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2388(200007\/08)19:1<3::AID-SSU2>3.0.CO;2-S"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.09.013"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.06.051"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603323"},{"issue":"2","key":"6","first-page":"207","article-title":"Staging classifications and clinical practice guidelines for gynaecological cancers","volume":"70","author":"J. 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