{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:20:49Z","timestamp":1753888849838,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"vor","delay-in-days":289,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Ophthalmological Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:bold>Purpose:<\/jats:bold> We report our experience of diagnosing and managing metastatic adenocarcinoma of the lungs with primary manifestation to the iris and the ciliary body with the purpose to raise clinical suspicion for systemic malignancy in the presence of undetected ocular mass along with other ocular manifestations.<\/jats:p><jats:p><jats:bold>Observations:<\/jats:bold> An 82\u2010year\u2010old male presented with a deterioration of vision and intense pain in the right eye since the day before. With his right eye, he suddenly discerned hand movements only. Intraocular pressure in the right eye was increased. Slit\u2013lamp biomicroscopy revealed a ciliary injection and hemorrhagic mass overlying the temporal half of the iris. The L\u20109 ultrasound biomicroscopy (UBM) scan documented the tumor completely infiltrating the iris and the ciliary body. We suspected a metastatic eye lesion. CT chest imaging showed a solid expansive formation of the right lung. At the Oncology Department, a fine needle aspiration biopsy was performed under the control of MSCT, which confirmed lung adenocarcinoma.<\/jats:p><jats:p><jats:bold>Conclusions and Importance:<\/jats:bold> Although very rarely, pathological changes in the uvea may indicate a metastatic occurrence that needs to be considered in the differential diagnosis. It is important to undergo a wide ophthalmological examination, which in this case included a standardized A\u2010scan echography and UBM, which confirmed the suspicion of a tumor lesion, followed by cooperation with other medical professionals in order to discover a primary diagnosis.<\/jats:p>","DOI":"10.1155\/2024\/5522370","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T12:49:27Z","timestamp":1729082967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Undetected Ocular Mass as a Critical Alert for Identifying Uveal Metastasis"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8171-8281","authenticated-orcid":false,"given":"Tea","family":"\u0160trbac","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2751-8067","authenticated-orcid":false,"given":"Biljana","family":"Kuzmanovi\u0107 Elabjer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2758-8396","authenticated-orcid":false,"given":"Antun","family":"Koprivanac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6900-4451","authenticated-orcid":false,"given":"Mladen","family":"Bu\u0161i\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,16]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.22608\/APO.201712"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2012.252"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30148-1"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2007.01550.x"},{"key":"e_1_2_12_5_2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/978-3-662-02371-6_20","volume-title":"Intraocular tumors","author":"Ossoinig K. C.","year":"1983"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00604-8"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249210"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.07.014"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/142408"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000285"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.4081\/cp.2011.e39"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-014-0901-z"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-236405"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.36491"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.8.1153"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2022.101269"},{"volume-title":"Iris metastasis from lung adenocarcinoma","year":"2022","author":"Kelly E.","key":"e_1_2_12_17_2"},{"key":"e_1_2_12_18_2","first-page":"89","article-title":"A case study of unusual etiology of anterior uveitis with ocular hypertension-iris metastasis of primary lung adenocarcinoma","volume":"73","author":"Lin A. D.","year":"2014","journal-title":"Hawai\u2032i Journal of Medicine & Public Health"}],"container-title":["Case Reports in Ophthalmological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2024\/5522370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T12:49:30Z","timestamp":1729082970000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2024\/5522370"}},"subtitle":[],"editor":[{"given":"Maurizio","family":"Battaglia Parodi","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/2024\/5522370"],"URL":"https:\/\/doi.org\/10.1155\/2024\/5522370","archive":["Portico"],"relation":{},"ISSN":["2090-6722","2090-6730"],"issn-type":[{"type":"print","value":"2090-6722"},{"type":"electronic","value":"2090-6730"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5522370"}}