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Cortisol concentrations and subjective stress levels were collected across the MIST. Repeated measures analyses of variance were conducted to measure the group differences in subjective and cortisol stress responses. Two\u2010sample <jats:italic>t<\/jats:italic>\u2010tests were conducted to detect the group differences in stress\u2010related brain activation and functional connectivity (FC).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The LR group exhibited an increase in cortisol concentration after the MIST, whereas the HR group exhibited a decrease in cortisol concentration after the MIST. The LR group exhibited higher activation in the left anterior insula and lower FC between the left orbitofrontal cortex (OFC) and the right temporal pole (TP) (all <jats:italic>p<\/jats:italic><jats:sub><jats:italic>FWE<\/jats:italic><\/jats:sub>\u2009&lt;\u20090.05). Mediation analyses revealed that the left anterior insula mediates the relationship between psychological resilience and depression and the left OFC\u2013right TP FC mediates the relationship between psychological resilience and anxiety.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Findings highlight that the anterior insula and OFC\u2013TP FC could be the critical neural mechanism underlying the interaction between psychological resilience and psychosocial stress. Moreover, higher anterior insula activation and lower OFC\u2013TP FC could be the crucial neural mechanism of individuals with low psychological resilience developing into depression\/anxiety when experiencing daily psychosocial stressors.<\/jats:p>","DOI":"10.1155\/2024\/5526584","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T07:51:21Z","timestamp":1729065081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Neural Mechanisms Underlying the Impact of Psychological Resilience on Psychosocial Stress 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