{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:01:49Z","timestamp":1785445309592,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Dentistry"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    <jats:italic>Introduction<\/jats:italic>\n                    . The tendency to use dental materials of plant origin is one of the prevailing trends in dentistry to reduce exposure to materials that could have some toxic impact in the long term.\n                    <jats:italic>Objective<\/jats:italic>\n                    . To evaluate the efficacy of calcium hydroxide combined with gingerols (Ginge\u2010Cal) as a novel obturation material for treating infected primary teeth and decreasing the recurrence of infection.\n                    <jats:italic>Materials and Methods<\/jats:italic>\n                    . The study was conducted on 30 lower primary molars with infected pulp for children aged 4\u20138 years. The sample was randomly divided into two groups depending on the tested obturation material: Ginge\u2010Cal group and the Metapex group. The evaluation was done by different parameters clinically and radiographically at various intervals up to 12 months.\n                    <jats:italic>Results<\/jats:italic>\n                    . Based on chi\u2010squared and McNamara\u2019s test with a 5% significance level, the clinical results indicated that Ginge\u2010Cal group was more effective than the Metapex group in reducing or eliminating pain (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.467) after 1 week, sensitivity to percussion (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.090) at 3 months of follow\u2010up, purulent swelling (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.444) at 6 and 9 months of follow\u2010up, fistula, and tooth mobility. The radiographic results, based on the periapical and furcation area radiolucency at 12 months of follow\u2010up, favored Ginge\u2010Cal group over the Metapex group (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.683), (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.456), respectively. There were no statistically significant differences in pathological root resorption and periodontal space. The differences within the Ginge\u2010Cal group were directly influenced by the time intervals in a statistically significant manner, ranging from (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.004) to (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001). The success percentage was 87.5% for Ginge\u2010Cal group and 64.3% for Metapex group.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . Ginge\u2010Cal can be considered a promising material for treating the infected root canal when used as an obturation material for the infected root canal. This trial is registered with\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05181813\">NCT05181813<\/jats:ext-link>\n                    .\n                  <\/jats:p>","DOI":"10.1155\/2024\/5528260","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T12:05:19Z","timestamp":1707393919000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of Calcium Hydroxide and Gingerols Mixture as a Novel Obturation Material for Infected Root in Primary Teeth: A Randomized Clinical Trial"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4645-9998","authenticated-orcid":false,"given":"Fathi A.","family":"Qasem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3031-9499","authenticated-orcid":false,"given":"Salwa M.","family":"Awad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5697-7337","authenticated-orcid":false,"given":"Rizk A.","family":"Elagamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1590\/0103-6440201601009"},{"key":"e_1_2_11_2_2","first-page":"20","article-title":"Obturating materials in primary teeth\u2014a review","volume":"6","author":"Chonat A.","year":"2018","journal-title":"Research & Reviews: Journal of Dental Sciences"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.DON.0000134291.03828.D1"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2018.2.21038"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/0970-4388.127051"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10005-1404"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.4314\/gjpas.v15i3-4.48561"},{"key":"e_1_2_11_8_2","article-title":"6-gingerol is the most potent anticancerous compound in ginger (Zingiber officinale Rosc.)","volume":"6","author":"Kumara M.","year":"2017","journal-title":"Journal of Developing Drugs"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/foods8060185"},{"key":"e_1_2_11_10_2","first-page":"84","article-title":"Anti-microbial efficacy of gingerols and calcium hydroxide mixture versus metapex on microorganism of infected root canal of primary teeth","volume":"21","author":"Qasem F. 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