{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:49:54Z","timestamp":1787017794531,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":239,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Toxicology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"\n Objective<\/jats:italic>\n . To investigate the antioxidant and hepatoprotective effects of ethanolic\n Mangifera indica<\/jats:italic>\n (\n M. indica<\/jats:italic>\n ) seed extract on carbon tetrachloride (CCl\n 4<\/jats:sub>\n )\u2010induced hepatotoxicity in albino rats.\n Methods<\/jats:italic>\n . Forty\u2010eight albino rats weighing (100\u2013150\u2009g) were used for hepatoprotective and toxicity experiments. Antioxidant activity was determined using the 2, 2\u2010diphenyl\u20101\u2010picrylhydrazyl (DPPH) assay. The toxicity of\n M. indica<\/jats:italic>\n seeds on the liver was evaluated by examining wellness parameters, body weight, and liver histological sections. The protective effects of 50\u2009mg\/kg and 100\u2009mg\/kg of seed extract on CCl\n 4<\/jats:sub>\n \u2010induced hepatotoxicity were investigated by evaluating hematological, renal, and liver function parameters, body weight, and liver histological sections.\n Results<\/jats:italic>\n . The antioxidant activity of the\n M. indica<\/jats:italic>\n ethanolic extract was (92\u2009\u00b1\u20090.03 RSA %) compared with (91\u2009\u00b1\u20090.01 RSA %) of propyl gallate, and the IC\n 50<\/jats:sub>\n was (8.3\u2009\u00b1\u20090.01\u2009\n \u00b5<\/jats:italic>\n g\/ml) and (14.1\u2009\u00b1\u20090.01\u2009\n \u00b5<\/jats:italic>\n g\/ml). No changes were observed in the health indicators, body weights, and liver histological sections following oral administration of 50\u2009mg\/kg and 100\u2009mg\/kg of\n M. indica<\/jats:italic>\n seed extracts. Treatment with\n M. indica<\/jats:italic>\n seed extract significantly reduced alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), blood sugar, and urea levels compared with those in the CCl\n 4<\/jats:sub>\n \u2010treated group.\n Conclusion<\/jats:italic>\n . The IC\n 50<\/jats:sub>\n of the\n M. indica<\/jats:italic>\n ethanolic extract was 8.3\u2009\n \u00b5<\/jats:italic>\n g\/ml, and the\n M. indica<\/jats:italic>\n extract is a potential source of natural antioxidants that protect against CCl\n 4<\/jats:sub>\n \u2010induced hepatotoxicity.\n <\/jats:p>","DOI":"10.1155\/2024\/5539386","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T07:48:29Z","timestamp":1724744909000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ethanolic Extract of\n Mangifera indica<\/i>\n Protects against CCl\n 4<\/sub>\n \u2010Induced Hepatotoxicity via Antioxidant Capabilities in Albino Rats"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3439-096X","authenticated-orcid":false,"given":"Ahmed 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