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In this study, we fed a diet containing 800\u2009mg\/kg of tannin on <jats:italic>Litopenaeus vannamei<\/jats:italic> for 56 days and then subjected to acute ammonia stress for 48\u2009hr to investigate the effect of dietary tannin on the ammonia stress response of <jats:italic>L. vannamei<\/jats:italic> through transcriptomic and metabolomic analysis. The transcriptome analysis indicated that ammonia stress\u2010induced differential expression of 4,185 genes, while tannin\u2010fed shrimp only had 964 differentially expressed genes. Compared with the TA_0 group, 59 pathways were significantly altered, and the pathways of \u201cstarch and sucrose metabolism,\u201d \u201cretinol metabolism,\u201d \u201carachidonic acid metabolism,\u201d \u201clysosome,\u201d and \u201camino sugar and nucleotide sugar metabolism\u201d were highly enriched in the TS_0 group. Compared with the TS_0 group, six pathways were significantly altered, and the pathways of \u201cdilated cardiomyopathy,\u201d \u201ccomplement and coagulation cascades,\u201d \u201ccardiac muscle contraction,\u201d \u201cfructose and mannose metabolism,\u201d \u201ccGMP\u2010PKG signaling pathway,\u201d and \u201cbeta\u2010alanine metabolism\u201d were significantly enriched in the TS_800 group. Metabolomic analysis showed that a total of 107 differential metabolites (DMs) were identified in the TS_0 vs. TA_0 group, while 75 DMs were identified in the TS_800 vs. TS_0 group. Based on KEGG annotation, it was found that a large amount of DM was significantly enriched in amino acid metabolism pathways in the TS_0 group, including \u201carginine and proline metabolism,\u201d \u201calanine, aspartic acid, and glutamic acid metabolism,\u201d \u201c<jats:italic>\u03b2<\/jats:italic>\u2010Alanine metabolism and tyrosine metabolism\u201d indicated that tannins affect the metabolism of amino acids. The integration of DEGs and DMs indicates that dietary tannins highly alter the digestion and absorption functions of proteins, as well as the biosynthesis and metabolism of amino acids. This study provides new insights into the adaptation of Pacific white shrimp to ammonia stress and the addition of tannins to feed to enhance immune function.<\/jats:p>","DOI":"10.1155\/2024\/5539701","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T21:05:11Z","timestamp":1715634311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Tannin Supplementation in Diet on the Resistance to Ammonia Stress of Pacific White Shrimp <i>Litopenaeus 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