{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T13:05:04Z","timestamp":1774184704616,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":247,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019446","name":"Medical and Health Science and Technology Development Project of Shandong Province","doi-asserted-by":"publisher","award":["202102040075"],"award-info":[{"award-number":["202102040075"]}],"id":[{"id":"10.13039\/501100019446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019446","name":"Medical and Health Science and Technology Development Project of Shandong Province","doi-asserted-by":"publisher","award":["2019WS243"],"award-info":[{"award-number":["2019WS243"]}],"id":[{"id":"10.13039\/501100019446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020QH084"],"award-info":[{"award-number":["ZR2020QH084"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR201807090175"],"award-info":[{"award-number":["ZR201807090175"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100842"],"award-info":[{"award-number":["82100842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070856"],"award-info":[{"award-number":["82070856"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:bold>Aim:<\/jats:bold> The aim of the study is to identify the regulatory role of intestinal sweet taste receptors (STRs) and glucose transporters (SGLT1, GLUT2) and gut peptide secretion in duodenal\u2013jejunal bypass (DJB)\u2013ameliorated glycemic control in Type 2 diabetes.<\/jats:p><jats:p><jats:bold>Materials and Methods:<\/jats:bold> DJB and sham surgeries were performed in streptozotocin\u2010induced diabetic male rats. The blood GLP\u20101 and GLP\u20102 levels were evaluated under feeding and fasting conditions. The expression of STRs (T1R2, T1R3), sweet taste signaling effector (G<jats:italic>\u03b1<\/jats:italic>\u2010gustducin), SGLT1, and GLUT2 was detected in the intestinal alimentary limb (A limb), biliopancreatic limb (BP limb), and common limb (C limb). The effects of STR inhibition on glucose control were measured with lactisole.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Glucose tolerance was improved in DJB\u2010operated rats compared with the sham group, similar to that of normal control rats, without significant differences in food intake and body weight. The plasma GLP\u20101 levels of DJB rats were increased under diet\u2010fed condition, and GLP\u20102 levels were increased after fasting. The villus height and crypt depth were significantly increased in the A limb of DJB\u2010operated rats. In addition, GLP\u20101 expression was restored in enterocytes. The expression of T1R2, G<jats:italic>\u03b1<\/jats:italic>\u2010gustducin, and SGLT1 was elevated in the A limb after DJB, while GLUT2 was downregulated in the A, BP, and C limbs. The localization of GLUT2 was normalized in the three intestinal limbs after DJB. However, the beneficial effects of DJB on glucose control were abolished in the presence of lactisole in vivo.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> DJB ameliorates glycemic control probably by restoring STR\u2010mediated glucose sensing and absorption with the responses of GLP\u20101 and GLP\u20102 to carbohydrate.<\/jats:p>","DOI":"10.1155\/2024\/5544296","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T13:08:45Z","timestamp":1725455325000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Duodenal\u2013Jejunal Bypass Restores Sweet Taste Receptor\u2010Mediated Glucose Sensing and Absorption in Diabetic Rats"],"prefix":"10.1155","volume":"2024","author":[{"given":"Sipeng","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongguan","family":"Kou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hantao","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengqi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yubing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingtao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meihua","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7603-3384","authenticated-orcid":false,"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0695-0627","authenticated-orcid":false,"given":"Zhiqin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-019-1772-x"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-017-2845-9"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2745"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-019-04153-3"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2021.02.011"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00741"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2018.08.009"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.04.008"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.10.009"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2019.04.008"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2018.00101"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-021-05871-3"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1586\/17474124.2014.887439"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182890311"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00405.2013"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-321402"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-014-9291-y"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2016.08.500"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-020-07741-y"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-019-07200-3"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0558"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-016-2345-3"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-015-1968-0"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181d3d21f"},{"key":"e_1_2_14_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1235103"},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2002-0306"},{"key":"e_1_2_14_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.11.3708"},{"key":"e_1_2_14_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04485.x"},{"key":"e_1_2_14_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-020-00976-w"},{"key":"e_1_2_14_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2017.1419366"},{"key":"e_1_2_14_31_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4959646"},{"key":"e_1_2_14_32_2","doi-asserted-by":"publisher","DOI":"10.2337\/db17-0058"},{"key":"e_1_2_14_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-020-01558-w"},{"key":"e_1_2_14_34_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.148932"},{"key":"e_1_2_14_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181d96e1f"},{"key":"e_1_2_14_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-013-0985-0"},{"key":"e_1_2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