{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:15:14Z","timestamp":1753888514642,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":232,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Ophthalmological Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> We describe a unique case of sclerouveitis that progressed to endogenous <jats:italic>Fusarium<\/jats:italic> endophthalmitis in a 69\u2010year\u2010old male with chronic lymphocytic leukemia (CLL). We highlight the risk of treating sclerouveitis with oral corticosteroids, which can exacerbate an infection and contribute to disease progression.<\/jats:p><jats:p><jats:bold>Case Presentation:<\/jats:bold> A 69\u2010year\u2010old male with CLL on zanubrutinib, a second\u2010generation Bruton\u2019s tyrosine kinase inhibitor, was admitted to the hospital for osteomyelitis of the left foot. At presentation, the patient also reported right eye pain for 1 week and vision loss over the course of 1 month. Vision in the right eye was hand motion. Slit lamp examination revealed scleral inflammation in the right eye with violaceous injection, chemosis, inflammation in the anterior chamber, and diffuse subconjunctival hemorrhage. There was significant corneal edema preventing fundus examination. B\u2010scan ultrasonography demonstrated a flat retina with no vitritis or scleral thickening. Forty\u2010eight hours after treatment with oral and topical corticosteroids, the patient\u2019s eye pain improved but his vision worsened. Repeat B\u2010scan showed new\u2010onset vitritis. Fungal culture obtained by diagnostic pars plana vitrectomy (PPV) revealed growth of <jats:italic>Fusarium<\/jats:italic>. The patient was treated with oral and intravitreal voriconazole in addition to intravenous voriconazole and amphotericin B for systemic therapy. Corticosteroids were discontinued. Despite aggressive therapy, the patient\u2019s disposition declined to the point of transitioning to comfort\u2010focused care, and he passed away.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Endogenous fungal endophthalmitis is most commonly seen in immunocompromised patients, and oral corticosteroid therapy for such patients should be used with caution as it can worsen an infection. In cases of fusarial endophthalmitis, visual prognosis is poor.<\/jats:p>","DOI":"10.1155\/2024\/5549818","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T09:50:11Z","timestamp":1724147411000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Progression of Sclerouveitis to Endogenous <i>Fusarium<\/i> Endophthalmitis"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7091-7144","authenticated-orcid":false,"given":"Sairi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8665-4499","authenticated-orcid":false,"given":"J. Anthony","family":"Chacko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3172-1217","authenticated-orcid":false,"given":"Riley N.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2770-6578","authenticated-orcid":false,"given":"Eric R.","family":"Rosenbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2967-3888","authenticated-orcid":false,"given":"Philip W.","family":"Dockery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7207-6782","authenticated-orcid":false,"given":"Ahmed B.","family":"Sallam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2018.1466561"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00113-16"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2023.02.011"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy140"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6736413"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1130595"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/IPC.0b013e31826ba107"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/18.4.585"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-013-9854-z"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S31652"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.1.42"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(94)95911-0"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1586\/eri.11.139"}],"container-title":["Case Reports in Ophthalmological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2024\/5549818","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T09:50:14Z","timestamp":1724147414000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2024\/5549818"}},"subtitle":[],"editor":[{"given":"Kamal","family":"Kishore","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/2024\/5549818"],"URL":"https:\/\/doi.org\/10.1155\/2024\/5549818","archive":["Portico"],"relation":{},"ISSN":["2090-6722","2090-6730"],"issn-type":[{"type":"print","value":"2090-6722"},{"type":"electronic","value":"2090-6730"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5549818"}}