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However, as optogenetics moves towards clinical trials, combinatorial photostimulation based on arrays of LED light sources has emerged. This approach inevitably brings about a large increase in transient temperature, resulting in the inability to achieve precise stimulation of cells. We designed a wireless optogenetic hardware system to realize the control of the stimulation mode and temperature of the light source array. At the same time, a set of combined photothermal physical model was established to simulate the photothermal response of the whole experiment. The physical model can effectively guide the wireless optogenetic hardware circuits to perform effective stimulation within a controlled temperature range. Our model provides a new technical approach for photothermal studies in optogenetic clinical trials.<\/jats:p>","DOI":"10.1155\/2024\/5562848","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T22:06:21Z","timestamp":1713305181000},"page":"1-19","source":"Crossref","is-referenced-by-count":4,"title":["A Photothermal Modelling Approach for Micro-LED Arrays in Wireless Optogenetics"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3460-9888","authenticated-orcid":true,"given":"Yanping","family":"Ji","sequence":"first","affiliation":[{"name":"Faculty of Information Technology, Beijing University of Technology, Beijing 100124, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanzhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Faculty of Information Technology, Beijing University of Technology, Beijing 100124, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Li","sequence":"additional","affiliation":[{"name":"Faculty of Information Technology, Beijing University of Technology, Beijing 100124, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2586-7881","authenticated-orcid":true,"given":"Wensi","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Information Technology, Beijing University of Technology, Beijing 100124, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9003-755X","authenticated-orcid":true,"given":"Mengyi","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Sociology, China University of Political Science and Law, Beijing 100091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1109\/IEMBS.2011.6090835"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007801"},{"key":"3","article-title":"Web resource: Changchun New Industry Optoelectronics Technology Co., Ltd, a subsidiary of Changchun Institute of Optics, Chinese Academy of Sciences, Optogenetics and Neuro-Optics Lasers product page"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2011.2114883"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2776"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2008.00460.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2396"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1718721115"},{"issue":"2","key":"9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nmeth.1808","article-title":"Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins","volume":"9","author":"J. 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