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We herein observed that the activation of Toll\u2010like receptor 3 (TLR3) by polyinosinic\u2009:\u2009polycytidylic acid (poly(I\u2009:\u2009C)) stimulation facilitated the transformation of adipose\u2010derived stem cells (ADSCs) into an anti\u2010inflammatory phenotype. The enhanced anti\u2010inflammatory properties were assessed in a taurocholate\u2010induced pancreatitis model. The results demonstrated that poly(I\u2009:\u2009C) pretreated ADSCs exhibited enhanced anti\u2010inflammatory properties than untreated ADSCs in taurocholate\u2010induced pancreatitis. Mechanistically, poly(I\u2009:\u2009C)\u2010treated ADSCs showed increased production and secretion of interleukin\u201010 (IL\u201010), which demonstrates a potent ability to alleviate inflammatory signaling cascades in acinar cells. Simultaneously, the heightened anti\u2010inflammatory effects of poly(I\u2009:\u2009C)\u2010treated ADSCs in pancreatitis were associated with the regulation of macrophage classical\/alternative transformation, thereby mitigating inflammatory factor\u2010mediated damage to the pancreatic acinar cell. 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