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Recognizing the importance of medicinal plants and the absence of specific medications for traumatic brain injury (TBI) treatment, this study was conducted to evaluate the effects of an aqueous extract of <jats:italic>Aloe vera<\/jats:italic> on oxidative stress, blood\u2013brain barrier (BBB) permeability, and neurological scores following TBI. <jats:italic>Materials and Methods<\/jats:italic>. Adult male rats were categorized into five groups: sham, TBI, vehicle, low\u2010dose <jats:italic>Aloe vera<\/jats:italic> (LA), and high\u2010dose <jats:italic>Aloe vera<\/jats:italic> (HA). We induced diffuse TBI using the Marmaro model and administered the aqueous <jats:italic>Aloe vera<\/jats:italic> leaf extract, as well as vehicle, via intraperitoneal injection half an hour after TBI. Neurological outcomes were assessed both before and several hours after TBI. Additionally, oxidative stress factors were measured 24\u2009hr after TBI, and Evans blue content (a BBB permeability index) was determined 5\u2009hr after TBI in both serum and brain. <jats:italic>Results<\/jats:italic>. Both LA and HA reduced the increase in BBB permeability after TBI, with HA having a more pronounced effect than LA. Both <jats:italic>Aloe vera<\/jats:italic> doses decreased brain MDA levels, increased brain TAC, and lowered both serum and brain PC levels. The impact of <jats:italic>Aloe vera<\/jats:italic> on brain oxidative parameters was more significant than on serum. HA also counteracted the declining effects of TBI on neurological outcomes at 4 and 24\u2009hr post\u2010TBI. <jats:italic>Conclusion<\/jats:italic>. This study suggests that <jats:italic>Aloe vera<\/jats:italic> extract may reduce BBB permeability and improve neurological outcomes after TBI by decreasing oxidative factors and increasing antioxidant factors.<\/jats:p>","DOI":"10.1155\/2024\/5586814","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T10:23:47Z","timestamp":1721039027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>Aloe vera<\/i> Leaf Extract Reduced BBB Permeability and Improved Neurological Results after Traumatic Brain Injury: The Role of Oxidative Stress"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0770-4281","authenticated-orcid":false,"given":"Mohammad","family":"Khaksari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0899-4244","authenticated-orcid":false,"given":"Marzieh","family":"Shahryari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0693-5048","authenticated-orcid":false,"given":"Alireza","family":"Raji-Amirhasani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8423-6189","authenticated-orcid":false,"given":"Zahra","family":"Soltani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6675-0806","authenticated-orcid":false,"given":"Bahram","family":"Bibak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0894-3815","authenticated-orcid":false,"given":"Zakieh","family":"Keshavarzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4813-6030","authenticated-orcid":false,"given":"Farzaneh","family":"Shakeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30231-X"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/msj.20104"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.2741\/3489"},{"key":"e_1_2_11_4_2","first-page":"411","article-title":"Outcome biomarkers following severe traumatic brain injury","volume":"20","author":"COd O.","year":"2008","journal-title":"Revista Brasileira de Terapia Intensiva"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2006.00351.x"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20174225"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.12.009"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399411001918"},{"key":"e_1_2_11_9_2","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020412","article-title":"The blood\u2013brain barrier","volume":"7","author":"Daneman R.","year":"2015","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21082721"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18788769"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2014.11.006"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16679420"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23300"},{"key":"e_1_2_11_15_2","article-title":"Regulatory situation of herbal medicines\u2014a world wide review","author":"Xiaorui Z.","year":"1998","journal-title":"Geneva: World Health Organization"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02907852"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(02)00048-X"},{"key":"e_1_2_11_18_2","unstructured":"CalvinJ. 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