{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:13:37Z","timestamp":1788470017355,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":184,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["2022xkjT009"],"award-info":[{"award-number":["2022xkjT009"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002729","name":"Anhui University","doi-asserted-by":"publisher","award":["gxbjZD2022013"],"award-info":[{"award-number":["gxbjZD2022013"]}],"id":[{"id":"10.13039\/501100002729","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870403"],"award-info":[{"award-number":["81870403"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:bold>Purpose:<\/jats:bold> Type 2 diabetes mellitus (T2DM) is associated with multiple neuropsychiatric impairments, including cognitive dysfunction, and melatonin (MLT) plays a crucial role in maintaining normal neuropsychiatric functions. This study is aimed at investigating the change in plasma MLT levels and its association with neuropsychiatric impairments in T2DM patients.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> One hundred twenty\u2010six T2DM patients were recruited, and their demographics and clinical data were collected. Apart from the plasma glycated hemoglobin (HbA1c) levels and other routine metabolic indicators, the plasma concentrations of MLT, C\u2010reactive protein (CRP), Interleukin 6 (IL\u20106), soluble myeloid triggered receptor 1 (sTREM 1), and receptor 2 (sTREM 2) were measured. Moreover, the executive function and depressive tendency were evaluated via the Behavior Rating Inventory of Executive Function\u2010Adult Version (BRIEF\u2010A) and the Epidemiological Research Center Depression Scale (CES\u2010D), respectively.<\/jats:p><jats:p><jats:bold>Result:<\/jats:bold> Compared with the low HbA1c group, the T2DM patients in the high HbA1c group presented lower plasma MLT levels but higher plasma concentrations of inflammatory biomarker levels, together with higher scores in the BRIEF\u2010A and CES\u2010D scales. Moreover, results of the Pearson correlation test showed that the plasma MLT levels were negatively correlated with the BRIEF\u2010A and CES\u2010D scores, as well as plasma concentrations of HbA1c and inflammatory indications, indicating that MLT may mediate their neuroinflammation and neuropsychiatric impairments. Furthermore, the ROC curve results indicated that plasma MLT levels have a predictive effect on executive impairment and depressive status in T2DM patients.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> MLT levels decreased in patients with T2DM and were associated with neuropsychiatric impairments and inflammatory status, and MLT might be developed as a therapeutic agent and predictive indicator for T2DM\u2010associated executive impairment and depression status.<\/jats:p>","DOI":"10.1155\/2024\/5661751","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T12:05:52Z","timestamp":1720008352000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Insufficient Plasma Melatonin and Its Association With Neuropsychiatric Impairments in Patients With T2DM"],"prefix":"10.1155","volume":"2024","author":[{"given":"Shuai","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-quan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-min","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-ran","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huai-zhi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6289-9934","authenticated-orcid":false,"given":"Jin-fang","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62154-6"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41387-023-00238-2"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn4019"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59903"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001982"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(12)70004-6"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.176"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70284-2"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-021-01590-x"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)70016-5"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2008-13302"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113375"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23116144"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-023-00837-1"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1106"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2016.1264072"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01544"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2018.05.008"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2019.07.025"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/1933719118770547"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2019.10.014"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101304"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12667"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202002247RR"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1590\/2359-3997000000098"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115846"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5566019"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14652"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.23736\/S0031-0808.20.03879-3"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.185"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4591938"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu7095341"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.020734"},{"key":"e_1_2_12_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26237213"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.01.002"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12482"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1068199"},{"key":"e_1_2_12_39_2","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S323009"},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01464-x"},{"key":"e_1_2_12_41_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170718110606"},{"key":"e_1_2_12_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12956"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-023-06056-6"},{"key":"e_1_2_12_44_2","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2023.230651"},{"key":"e_1_2_12_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-022-05747-w"},{"key":"e_1_2_12_46_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.7649"},{"key":"e_1_2_12_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbscr.2017.06.001"},{"key":"e_1_2_12_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12584"},{"key":"e_1_2_12_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-024-06118-3"}],"container-title":["Journal of Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2024\/5661751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T17:03:16Z","timestamp":1735837396000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2024\/5661751"}},"subtitle":[],"editor":[{"given":"Kazuya","family":"Yamagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/2024\/5661751"],"URL":"https:\/\/doi.org\/10.1155\/2024\/5661751","archive":["Portico"],"relation":{},"ISSN":["2314-6745","2314-6753"],"issn-type":[{"value":"2314-6745","type":"print"},{"value":"2314-6753","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5661751"}}