{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:10:20Z","timestamp":1790727020481,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":259,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. This study aimed to examine whether repeated measurements on noninvasive fibrosis scores during follow\u2010up improve long\u2010term nonalcoholic fatty liver disease (NAFLD) outcome prediction. <jats:italic>Methods<\/jats:italic>. A cohort study of 2,280 NAFLD patients diagnosed at the Seoul National University Hospital from 2001 to 2015 was conducted. Multivariable Cox regression models with baseline and designated time\u2010point measurements of the fibrosis\u20104 index (FIB\u20104) and NAFLD fibrosis score (NFS) were used to assess the association between these scores and overall mortality, liver\u2010related outcomes, and cardiovascular events. <jats:italic>Results<\/jats:italic>. Higher baseline NFS (high versus low probability for advanced fibrosis groups) was associated with higher risk of mortality (adjusted hazard ratio (aHR), (95% confidence interval (CI)), 2.80, [1.39\u20135.63]) and liver\u2010related outcomes (3.70, [1.27\u201310.78]). Similar findings were observed for the association of baseline FIB\u20104 with mortality (2.49, [1.46\u20134.24]) and liver\u2010related outcomes (11.50, [6.17\u201321.44]). In models considering designated time\u2010point measurements of the scores, stronger associations were noted. For NFS, a higher time\u2010point measurement was associated with a significantly higher risk of mortality (3.01, [1.65\u20135.49]) and liver\u2010related outcomes (6.69, [2.62\u201317.06]). For FIB\u20104, higher time\u2010point measurements were associated with significantly higher mortality (3.01, [1.88\u20134.82]) and liver\u2010related outcomes (13.26, [6.89\u201325.53]). An annual increase in FIB\u20104 (2.70, [1.79\u20134.05]) or NFS (4.68, [1.52\u201314.44]) was associated with an increased risk of liver\u2010related outcomes. No association between NFS\/FIB\u20104 and risk of cardiovascular events was observed in both models. <jats:italic>Conclusions<\/jats:italic>. Higher aHRs describing the associations of FIB\u20104\/NFS with overall mortality and liver\u2010related outcomes were observed in the models that included designated time\u2010point measurements of the scores. In addition to the baseline measurement, a routine monitoring on these scores may be important in predicting prognosis of NAFLD patients.<\/jats:p>","DOI":"10.1155\/2024\/5667986","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T12:03:38Z","timestamp":1726488218000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Predictive Value of Time\u2010Varying Noninvasive Scores on Long\u2010Term Prognosis of NAFLD in South Korea"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7263-6866","authenticated-orcid":false,"given":"Sung Won","family":"Chung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6065-3367","authenticated-orcid":false,"given":"Min 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