{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:29:07Z","timestamp":1768318147776,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":119,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Orofacial granulomatosis (OFG) is a rare disease entity characterized by nonnecrotizing granulomatous inflammation in the oral and maxillofacial regions, typically characterized by recurrent or persistent edema, primarily in the lips and occasionally in the gingiva. OFG is often associated with Crohn\u2019s disease and sarcoidosis, and an accurate diagnosis requires systemic examination of patients. Pediatric patients possess unique oral conditions where dental plaque rapidly forms, especially during tooth replacement due to tooth crowding. Moreover, controlling oral hygiene can be challenging, rendering it difficult to distinguish plaque\u2010induced gingivitis from nonplaque\u2010induced gingivitis. We elucidate the reports of pediatric patients who developed OFG in the lips and\/or gingiva alone, which was well controlled through corticosteroid treatment. The patients demonstrated recurrent lips and\/or gingival swelling with redness, which failed to improve despite oral health care and treatment with antibiotics and\/or corticosteroid ointment. Incision biopsy was performed, which demonstrated granulomatous inflammation. Further systemic examination ruled out Crohn\u2019s disease and sarcoidosis and confirmed OFG diagnosis. Corticosteroid treatment orally or through gargling was administered to the patients, which provided improvement of symptoms after 1\u2009month. As OFG may be associated with intractable diseases, monitoring the patient regularly is crucial. Pediatric patients with OFG require a collaborative approach with pediatricians and pediatric dentists to manage their oral and overall health.<\/jats:p>","DOI":"10.1155\/2024\/5685686","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T20:50:06Z","timestamp":1714423806000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Orofacial Granulomatosis among Pediatric Patients Well Controlled by Corticosteroid Treatment: A Rare Case Series"],"prefix":"10.1155","volume":"2024","author":[{"given":"Taku","family":"Kimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3276-0154","authenticated-orcid":false,"given":"Ken-Ichiro","family":"Sakata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunichiro","family":"Takezaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Asaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Yanagawa-Matsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimasa","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20185828"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00591.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-3-26"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14390"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/11795476231160046"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2008.01500.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1542-3565(05)00424-6"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200208000-00010"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199102000-00008"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000369810"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.15.e456"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2002.01466.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.02.084"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.idoj_398_21"},{"key":"e_1_2_7_15_2","first-page":"ZE01","article-title":"Gingival diseases in childhood\u2013 a review","volume":"8","author":"Pari A.","year":"2014","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2020.e00924"},{"key":"e_1_2_7_17_2","first-page":"E440","article-title":"Cinnamon products as a possible etiologic factor in orofacial granulomatosis","volume":"12","author":"Endo H.","year":"2007","journal-title":"Medicina Oral, Patolog\u00eda Oral y Cirug\u00eda Bucal"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124x.100934"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-018-00997-w"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1995.tb04415.x"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1046-199x(97)90034-8"},{"key":"e_1_2_7_22_2","first-page":"594","article-title":"Oral changes in Crohn\u2019s disease","volume":"34","author":"Snyder M. 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