{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:36:38Z","timestamp":1792046198964,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":240,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","award":["LJKQZ20222370"],"award-info":[{"award-number":["LJKQZ20222370"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008844","name":"Liaoning University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2100220171"],"award-info":[{"award-number":["2100220171"]}],"id":[{"id":"10.13039\/501100008844","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008844","name":"Liaoning University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["zyzx2006"],"award-info":[{"award-number":["zyzx2006"]}],"id":[{"id":"10.13039\/501100008844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Neurology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    The objective of the study is to investigate whether quercetin ameliorates Alzheimer\u2019s disease (AD)\u2013like pathology in APP\/PS1 double transgenic mice and its hypothesized mechanism, contributing to the comprehension of AD pathogenesis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    A total of 30 APP\/PS1 transgenic mice were randomized into model group (APP\/PS1), quercetin group (APP\/PS1+Q), and donepezil hydrochloride group (APP\/PS1+DON). Simultaneously, there were 10 C57 mice of the same age served as a control group. Three months posttreatment, the effects of quercetin on AD mice were evaluated using the Morris water maze (MWM) test, Y maze experiment, immunohistochemistry, immunofluorescence, and western blotting.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Results from the water maze and Y maze indicated that quercetin significantly improved cognitive impairment in APP\/PS1 transgenic AD mice. Additionally, serum enzyme\u2010linked immunosorbent assay (ELISA) results demonstrated that quercetin elevated MDA, superoxide dismutase (SOD), CAT, GSH, acetylcholine (ACh), and acetylcholinesterase (AChE) levels in AD mice. Hematoxylin\u2010eosin (HE) staining, Nissl staining, and hippocampal tissue thioflavine staining revealed that quercetin reduced neuronal damage and A\n                    <jats:italic>\u03b2<\/jats:italic>\n                    protein accumulation in AD mice. Western blot validated protein expression in the Kelch\u2010like ECH\u2010associated protein 1 (Keap1)\/nuclear factor erythroid 2\u2013related factor 2 (Nrf2)\/HO\u20101 pathway associated with oxidative stress and apoptosis, confirming quercetin\u2019s potential molecular mechanism of enhancing AD mouse cognition. Furthermore, western blot findings indicate that quercetin significantly alters protein expression in the Keap1\/Nrf2\/HO\u20101 pathway. Moreover, molecular docking analysis suggests that Keap1, NQO1, HO\u20101, caspase\u20103, Bcl\u20102, and Bax proteins in the Keap1\/Nrf2\/HO\u20101 pathway may be potential regulatory targets of quercetin. These findings will provide a molecular basis for quercetin\u2019s clinical application in AD treatment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Quercetin can improve cognitive impairment and AD\u2010like pathology in APP\/PS1 double transgenic mice, potentially related to quercetin\u2019s activation of the Keap1\/Nrf2\/HO\u20101 pathway and reduction of cell apoptosis.\n                  <\/jats:p>","DOI":"10.1155\/2024\/5698119","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T06:18:15Z","timestamp":1724825895000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Quercetin Attenuates Oxidative Stress and Apoptosis in Brain Tissue of APP\/PS1 Double Transgenic AD Mice by Regulating Keap1\/Nrf2\/HO\u20101 Pathway to Improve Cognitive 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