{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:38:12Z","timestamp":1753886292656,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":285,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:bold>Objective<\/jats:bold>: To evaluate the effectiveness of empagliflozin in reducing all\u2010cause mortality (ACM), hospitalization for heart failure (HHF), myocardial infarction (MI), stroke, cardiovascular mortality (CVM), and end\u2010stage renal disease (ESRD) in routine clinical practice in the Nordic countries of the Empagliflozin Comparative Effectiveness and Safety (EMPRISE) study.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold>: This noninterventional, multicountry cohort study used secondary data from four Nordic countries (Denmark, Sweden, Finland, and Norway). Propensity score (PS) matched (1:1) adults with type 2 diabetes (T2D) initiating empagliflozin (a sodium\u2010glucose cotransporter\u20102 inhibitor) during 2014\u20132018 who were compared to those initiating a dipeptidyl peptidase\u20104 inhibitor (DPP\u20104i). Cox proportional hazards regression modelling was used to assess the risk for ACM, HHF, MI, stroke, CVM, and ESRD. Meta\u2010analyses were conducted and hazard ratios (HRs) with 95% confidence intervals (CIs) from random\u2010effects models were calculated.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold>: A total of 43,695 pairs of PS\u2010matched patients were identified. Patients initiating empagliflozin exhibited a 49% significantly lower risk of ACM (HR: 0.51, 95% CI 0.40\u20130.64) compared to DPP\u20104i. Additionally, empagliflozin was associated with a 36% significantly lower risk of HHF (HR: 0.64, 95% CI 0.46\u20130.89), a 52% significantly lower risk of CVM (HR: 0.48, 95% CI 0.37\u20130.63), and a 66% significantly lower risk of ESRD (HR: 0.34, 95% CI 0.15\u20130.77) compared to DPP\u20104i. No significant differences were observed in the risk of stroke and MI between patients initiating empagliflozin compared with those initiating a DPP\u20104i. Results were generally consistent for subgroups (with\/without pre\u2010existing CV disease or congestive heart failure) and in sensitivity analyses.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold>: Empagliflozin initiation was associated with a significantly reduced risk of ACM, HHF, CVM, and ESRD compared with initiation of DPP\u20104i in patients with T2D when examining routine clinical practice data from Nordic countries.<\/jats:p>","DOI":"10.1155\/2024\/6142211","type":"journal-article","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T11:49:10Z","timestamp":1728733750000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Empagliflozin Use Is Associated With Lower Risk of All\u2010Cause Mortality, Hospitalization for Heart Failure, and End\u2010Stage Renal Disease Compared to DPP\u20104i in Nordic Type 2 Diabetes Patients: Results From the EMPRISE (Empagliflozin Comparative Effectiveness and Safety) Study"],"prefix":"10.1155","volume":"2024","author":[{"given":"Gisle","family":"Langslet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Nystr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorte","family":"Vistisen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bendix","family":"Carstensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie Toresson","family":"Grip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2733-5436","authenticated-orcid":false,"given":"Paula","family":"Casajust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgi","family":"Tskhvarashvili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Hoti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riho","family":"Klement","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Karlsdotter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"Tuovinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Pernille","family":"Ofstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Lajer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8310-7043","authenticated-orcid":false,"given":"Christina","family":"Shay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisette","family":"Koeneman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soulmaz Fazeli","family":"Farsani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Niskanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7561-7644","authenticated-orcid":false,"given":"Sigrun","family":"Halvorsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,12]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjr.0000368191.86614.5a"},{"key":"e_1_2_13_2_2","unstructured":"FederationI. 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