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Mesenchymal stem cells (MSCs) have been proven to have beneficial therapeutic effects in many human diseases. Here, a CGU model induced by acetic acid in mice was used to evaluate the repair effects and potential mechanism of human umbilical cord\u2010derived MSCs (hUC\u2010MSCs) and hUC\u2010MSCs derived conditioned medium (hUC\u2010MSC\u2010CM). We found that hUC\u2010MSCs and hUC\u2010MSC\u2010CM treatment significantly repaired morphological characteristics of CGU, improved proliferation and decreased apoptosis of gastric cells, and promoted the generation of new blood vessels in granulation tissues. In addition, we could detect the homing of MSCs in gastric tissue, and MSCs may differentiate into Lgr5\u2010positive cells. As well as this, in vitro experiments showed that hUC\u2010MSC\u2010CM could promote cell proliferation, stimulate cell cycle progression, and reduce the incidence of apoptosis. The transcriptome of cells and the iTRAQ proteome of gastric tissues suggest that MSCs may play a therapeutic role by increasing the expression of TRIM29. Additionally, it was found that knocking down TRIM29 significantly decreased the ameliorative effects of hUC\u2010MSC\u2010CM on cell apoptosis. As a result of further molecular experiments, it was found that TRIM29 is capable of phosphorylating Erk\/Akt in specific cell type. As a whole, it appears that hUC\u2010MSCs can be an effective therapeutic approach for promoting gastric ulcer healing and may exert therapeutic effects in the form of paracrine and differentiation into gastric cells.<\/jats:p>","DOI":"10.1155\/2024\/6202123","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T20:05:20Z","timestamp":1704312320000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mesenchymal Stem Cells Accelerate Recovery of Acetic Acid\u2010Induced Chronic Gastric Ulcer by Regulating Ekt\/Akt\/TRIM29 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