{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:37:39Z","timestamp":1760189859051,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Clinical Practice"],"published-print":{"date-parts":[[2024,2,15]]},"abstract":"<jats:p>Background. Rates of major bleeding and intraprocedural thrombotic events (IPTE) in the setting of percutaneous coronary intervention (PCI) using weight-adjusted unfractionated heparin (UFH) without activated clotting time (ACT) monitoring are not known. Methods. We reviewed 2,748 consecutive patients who underwent coronary angiography at our tertiary care university hospital between January 2017 and December 2020. All patients who underwent PCI with weight-adjusted UFH without ACT guidance were considered for further analysis. Major bleeding complications occurring within 48\u2009hours of PCI were collected from patients\u2019 medical records. IPTE were collected independently by two interventional cardiologists after review of coronary angiograms. Results. There were 718 patients included in the analysis (65.4\u2009\u00b1\u200912.2\u2009years old; 81.3% male). In total, 45 patients (7.8%) experienced a major bleed or IPTE. The most common IPTE were slow\/no reflow (1.5%) and coronary artery dissection with decreased flow (1.1%). Other IPTE occurred in &lt;1% of cases. Major bleeding occurred in 11 patients (1.5%), of whom 8 required blood transfusion and 3 required vascular intervention. Bleeding complications were more common with femoral compared with radial access (6.6% vs. 0.2%, <jats:inline-formula><a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><a:mi>P<\/a:mi><a:mo>&lt;<\/a:mo><a:mn>0.001<\/a:mn><\/a:math><\/jats:inline-formula>). Conclusion. Weight-adjusted UFH use during PCI without ACT monitoring was related to low rates of major bleeding or IPTE.<\/jats:p>","DOI":"10.1155\/2024\/6219301","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T17:20:19Z","timestamp":1708017619000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Percutaneous Coronary Intervention with Procedural Unfractionated Heparin without Activated Clotting Time Guidance: A Unique Opportunity to Assess Thrombotic and Bleeding Events"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6888-5429","authenticated-orcid":true,"given":"Ali Z.","family":"Zgheib","sequence":"first","affiliation":[{"name":"American University of Beirut Medical Center, Division of Cardiology, Beirut, Lebanon"},{"name":"McGill University Health Centre, Division of Cardiology, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Jdaidani","sequence":"additional","affiliation":[{"name":"American University of Beirut Medical Center, Division of Cardiology, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elie","family":"Akl","sequence":"additional","affiliation":[{"name":"McGill University Health Centre, Division of Cardiology, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzan","family":"Khalil","sequence":"additional","affiliation":[{"name":"University of California at Los Angeles, Division of Cardiology, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Chaabo","sequence":"additional","affiliation":[{"name":"American University of Beirut Medical Center, Division of Cardiology, Beirut, Lebanon"},{"name":"McGill University Health Centre, Division of Cardiology, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolo","family":"Piazza","sequence":"additional","affiliation":[{"name":"McGill University Health Centre, Division of Cardiology, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadi J.","family":"Sawaya","sequence":"additional","affiliation":[{"name":"American University of Beirut Medical Center, Division of Cardiology, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2182-3298","authenticated-orcid":true,"given":"Abdallah G.","family":"Rebeiz","sequence":"additional","affiliation":[{"name":"American University of Beirut Medical Center, Division of Cardiology, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1161\/circinterventions.109.884478"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0b013e31823ba622"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.103.24.2994"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199105303242206"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960170704"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.103.7.961"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.12.003"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1161\/circinterventions.118.006084"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1161\/circinterventions.114.002044"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy394"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(11)60404-2"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(15)60292-6"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.iccl.2019.08.003"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2020.09.005"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.4852"},{"issue":"3100705","key":"16","article-title":"Corrigendum to A-41 | percutaneous coronary intervention with procedural unfractionated heparin without activated clotting time guidance: a unique opportunity to assess thrombotic and bleeding events","volume":"2","author":"A. 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Zgheib","year":"2023","journal-title":"Journal of the Society for Cardiovascular Angiography and Interventions"}],"container-title":["International Journal of Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijclp\/2024\/6219301.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijclp\/2024\/6219301.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijclp\/2024\/6219301.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T17:20:22Z","timestamp":1708017622000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ijclp\/2024\/6219301\/"}},"subtitle":[],"editor":[{"given":"Pietro","family":"Scicchitano","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,2,15]]},"references-count":16,"alternative-id":["6219301","6219301"],"URL":"https:\/\/doi.org\/10.1155\/2024\/6219301","relation":{},"ISSN":["1742-1241","1368-5031"],"issn-type":[{"type":"electronic","value":"1742-1241"},{"type":"print","value":"1368-5031"}],"subject":[],"published":{"date-parts":[[2024,2,15]]}}}