{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:05:56Z","timestamp":1793127956060,"version":"4.5.0"},"reference-count":235,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"vor","delay-in-days":159,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001336","name":"University of the Witwatersrand, Johannesburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nutrition and Metabolism"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    Lycopene is a naturally occurring carotenoid predominantly found in tomatoes and tomato\u2010based products. Like other phytochemicals, it exhibits health beneficial biological activities that can be exploited when it is used as a dietary supplement.\n                    <jats:italic>In vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    , lycopene has been demonstrated to mitigate oxidative stress\u2010induced metabolic dysfunctions and diseases including inflammation, obesity, and diabetes mellitus. Lycopene has been shown to alleviate metabolic diseases that affect the bone, eye, kidney, liver, lungs, heart, and nervous system. This review presents the state of the art regarding lycopene\u2019s health benefits and its potential applications in health system delivery. Furthermore, lycopene\u2019s protective effects against toxins, safety in its use, and possible toxicity are explored.\n                  <\/jats:p>","DOI":"10.1155\/2024\/6252426","type":"journal-article","created":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T05:03:25Z","timestamp":1717823005000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Lycopene: A Potent Antioxidant with Multiple Health Benefits"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3850-329X","authenticated-orcid":false,"given":"Mercy Omoye","family":"Shafe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nontobeko Myllet","family":"Gumede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor Tapiwa","family":"Nyakudya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliton","family":"Chivandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,8]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-7847.95849"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.4172\/2153-2435.1000e139"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/504253"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10030342"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijfs.14260"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020232"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9080706"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.18203\/2320-6012.ijrms20200804"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)00103-5"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408690091189275"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1039\/c9fo00580c"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS24076382"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/FSN3.3523"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2023.2205051"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.18203\/2319-2003.IJBCP20190565"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ADVANCES\/NMAA069"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/NU11071562"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.31989\/bchd.v5i10.975"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2020.158617"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.17140\/AFTNSOJ-6-163"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201801045"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140714620"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.13005\/BPJ\/1335"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.PHRS.2020.104966"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.LWT.2020.109323"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.PHRS.2007.01.012"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/09168451.2016.1249454"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.29088\/gmjm.2018.45"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.11648\/j.wjac.20200502.13"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.food.102308.124120"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/S11095-013-1104-6"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/JN\/138.3.482"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.126384"},{"key":"e_1_2_12_34_2","article-title":"Lycopene of tomato fame: its role in health and disease","volume":"10","author":"Chauhan K.","year":"2011","journal-title":"International Journal of Pharmaceutical Sciences Review and Research"},{"key":"e_1_2_12_35_2","doi-asserted-by":"publisher","DOI":"10.5772\/INTECHOPEN.104537"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2000.10718953"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.18805\/ag.R-1741"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/JN\/133.12.4189"},{"key":"e_1_2_12_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/S11696-021-01611-0"},{"key":"e_1_2_12_40_2","first-page":"1377","article-title":"Lycopene and Beta-carotene induce cell-cycle arrest and apoptosis in Human breast cancer cell lines","volume":"34","author":"Gloria N. 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