{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:30:12Z","timestamp":1782855012934,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":260,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["U01HL114197"],"award-info":[{"award-number":["U01HL114197"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM109036"],"award-info":[{"award-number":["P20GM109036"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007875","name":"Tulane University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007875","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Hypertension"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Uncontrolled hypertension is a major public health challenge in low\u2010 and middle\u2010income countries. The Hypertension Control Program in Argentina (HCPIA) showed that a community health worker\u2010led multicomponent intervention was effective for blood pressure (BP) reduction in resource\u2010limited settings, but whether the intervention was equally effective across participant subgroups is unknown.\n                    <jats:italic>Objective<\/jats:italic>\n                    . To identify participants who benefit the most from the HCPIA BP control intervention.\n                    <jats:italic>Methods<\/jats:italic>\n                    . This secondary analysis used data from HCPIA, a successful 18\u2010month cluster\u2010randomized trial in 18 health centers with 1,432 low\u2010income hypertensive patients in Argentina. Fifteen baseline characteristics were used to define subgroups. The proportion of controlled BP (&lt;140\/90\u2009mmHg) was estimated using generalized linear mixed models with arm\u2010by\u2010subgroup interaction terms. The distribution of trial BP response among intervention patient subgroups was assessed.\n                    <jats:italic>Results<\/jats:italic>\n                    . Participants were 53.0% female, a mean age of 56\u2009years, and 17.4% controlled BP at baseline. After the intervention, 72.9% of intervention and 52.2% of control participants had controlled BP. The intervention was more effective in physically inactive patients (OR\u2009=\u20092.76, 95% CI: 1.82 and 4.21;\n                    <jats:italic>p<\/jats:italic>\n                    for interaction\u2009=\u20090.04), moderately active patients (OR\u2009=\u20093.08, 95% CI: 1.90 and 4.99;\n                    <jats:italic>p<\/jats:italic>\n                    for interaction\u2009=\u20090.03), and those with uncontrolled BP at baseline (OR\u2009=\u20092.77, 95% CI: 2.15 and 3.57;\n                    <jats:italic>p<\/jats:italic>\n                    for interaction\u2009=\u20090.05). Among intervention participants, 20.2% had no BP response (BP change\u2009&lt;\u2009\u22124\u2009mmHg), 41.3% had a moderate BP response (BP change: \u22124\u2009mmHg to \u221224\u2009mmHg), and 38.5% had a high BP response (BP change\u2009&gt;\u2009\u221224\u2009mmHg). Women (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.01), those who were physically inactive (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.03), and those not taking antihypertensive medications at baseline (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.001) had the greatest BP response.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . The effect of the intervention was consistent across many subgroups with some key groups showing a particularly strong intervention effect. These findings could be useful for planning future hypertension control programs in low\u2010 and middle\u2010income countries.\n                  <\/jats:p>","DOI":"10.1155\/2024\/6311938","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T12:20:01Z","timestamp":1726575601000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identifying Who Benefits the Most from a Community Health Worker\u2010Led Multicomponent Intervention for Hypertension"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6734-0865","authenticated-orcid":false,"given":"Meng","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6397-4406","authenticated-orcid":false,"given":"Andrea","family":"Beratarrechea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3339-2421","authenticated-orcid":false,"given":"Rosana","family":"Poggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8989-0297","authenticated-orcid":false,"given":"Hua","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8895-9651","authenticated-orcid":false,"given":"Chung-Shiuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9035-9126","authenticated-orcid":false,"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6100-1862","authenticated-orcid":false,"given":"Vilma","family":"Irazola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8418-6134","authenticated-orcid":false,"given":"Adolfo","family":"Rubinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8286-9652","authenticated-orcid":false,"given":"Jiang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4278-5788","authenticated-orcid":false,"given":"Katherine T.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(18)32225-6"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(15)01225-8"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0244-2"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.115.018912"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2007.01.011"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180640"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/m17-1805"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.11358"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2016.09.004"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.24.2857"},{"key":"e_1_2_9_11_2","volume-title":"Who Benefits the Most from a Community Health Worker-Led Multicomponent Intervention for Hypertension? Secondary Analysis of the Hypertension Control Program in Argentina","author":"Pan M.","year":"2020"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/heapol\/czj011"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/maj.0000000000000298"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2019.05.011"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/hjh.0b013e32832aa6d2"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.03.010"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.113.000718"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.8014"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-198601000-00007"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1197\/aemj.9.4.330"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2018.06.003"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.22559"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmedr.2018.05.002"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1911965"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/jac.0000000000000108"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.7812\/tpp\/17-025"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.07.008"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.117.08317"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.119.12787"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13691"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyh299"}],"container-title":["International Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2024\/6311938","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/2024\/6311938","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2024\/6311938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:29:52Z","timestamp":1782851392000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2024\/6311938"}},"subtitle":[],"editor":[{"given":"Peng","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/2024\/6311938"],"URL":"https:\/\/doi.org\/10.1155\/2024\/6311938","archive":["Portico"],"relation":{},"ISSN":["2090-0384","2090-0392"],"issn-type":[{"value":"2090-0384","type":"print"},{"value":"2090-0392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6311938"}}