{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:41:44Z","timestamp":1789177304544,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":163,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Common postoperative complications following surgery, particularly acute appendicitis surgery, include postoperative pain and vomiting, which can cause discomfort and delay recovery time. <jats:italic>Methods<\/jats:italic>. A randomized double\u2010blinded placebo\u2010controlled clinical trial was conducted with 80 cases of acute appendicitis of American Society of Anesthesiologists (ASA) physical status I or II and aged 18\u201360\u2009y\/o scheduled for appendectomy under general anesthesia. Patients were randomly divided into two equal groups: group A received 4\u2009mg of ondansetron IV (2\u2009ml) and group B received 2\u2009ml of normal slain IV (placebo). Pain according to VAS, nausea and vomiting according to clinical symptoms, shivering and sedation according to the Bedside Shivering Assessment Scale (BSAS), and the Ramsay Sedation Scale (RSS) at 2, 6, 12, and 24\u2009hours after surgery were evaluated and compared between the groups. <jats:italic>Results<\/jats:italic>. There was a significant decline in the severity of pain only at 2\u2009hours after surgery between the ondansetron and control groups (5.3\u2009\u00b1\u20091.0 vs. 6.0\u2009\u00b1\u20091.0; <jats:italic>p<\/jats:italic> = 0.01), not showing a difference between the groups at 6, 12, and 24\u2009hours after appendectomy. Postoperative nausea and vomiting at 2 (5% vs. 25%; <jats:italic>p<\/jats:italic> = 0.03) and 6 (7.5% vs. 27.5%; <jats:italic>p<\/jats:italic> = 0.04) hours after appendectomy in the ondansetron group. At different times, the ondansetron and control groups did not differ in terms of pethidine consumption or sedation. <jats:italic>Conclusions<\/jats:italic>. In conclusion, our study found that ondansetron was effective in reducing postoperative vomiting after acute appendicitis surgery. However, it did not show a clinically significant effect on postoperative pain. This trial is registered with <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/IRCT20230722058883N1\">IRCT20230722058883N1<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2024\/6429874","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T23:48:42Z","timestamp":1718236122000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Ondansetron on Postoperative Pain and Vomiting after Acute Appendicitis Surgery: A Placebo\u2010Controlled Double\u2010Blinded Randomized Clinical Trial"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0185-8733","authenticated-orcid":false,"given":"Moein","family":"Khoori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3522-8772","authenticated-orcid":false,"given":"Peyman","family":"Mirghaderi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3399-2360","authenticated-orcid":false,"given":"Alireza","family":"Azarboo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8846-9538","authenticated-orcid":false,"given":"Forough","family":"Jamil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Eshraghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4039-7941","authenticated-orcid":false,"given":"Alireza Abdollahzadeh","family":"Baghaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1526-5900(03)00640-0"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.06.004"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.8562"},{"key":"e_1_2_13_4_2","volume-title":"Phipps\u2032 Medical-Surgical Nursing Health & Illness Perspectives","author":"Phipps M. 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