{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T15:38:37Z","timestamp":1776353917390,"version":"3.51.2"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":249,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold>Herpes zoster (HZ) is typically characterized by a burning, stabbing pain, hyperalgesia, and allodynia. In some patients, despite the lesions resolving, the pain persists and becomes chronic. If the pain continues for more than 6\u2009months after the onset of the pain phase, this condition is called postherpetic neuralgia (PHN). The frequency and severity of PHN increase with advancing age. The pain in PHN can be severe, sometimes resistant to medications, significantly impacting the patients\u2019 quality of life. The elderly patient population cannot tolerate the medications due to their side effects. In this situation, interventional pain treatment should be applied in the elderly patient group who have a high risk of developing PHN compared to other age groups.<\/jats:p><jats:p><jats:bold>Method:<\/jats:bold>We included patients over 65\u2009years of age with HZ\u2010related pain who underwent dorsal root ganglion (DRG) pulsed radiofrequency (PRF) within the first 6\u2009months from the onset of pain. We divided these patients into 2 groups: patients who underwent intervention within the first 1\u2009month from the onset of pain and patients who underwent intervention between 1 and 6\u2009months. We recorded medication doses and Numeric Rating Scale (NRS) scores before the procedure and at 1\u2009week, 1\u2009month, 3\u2009months, and 6\u2009months after the procedure.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold>After the DRG PRF treatment, NRS scores improved significantly in both groups (<jats:italic>p<\/jats:italic>&lt; 0.05). The mean NRS score in the early DRG PRF group was significantly lower than that in the late DRG PRF group (<jats:italic>p<\/jats:italic>&lt; 0.05). The medication doses in the early DRG PRF group were significantly lower than those in the other group (<jats:italic>p<\/jats:italic>&lt; 0.05).<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold>: Interventional pain treatment should be applied as soon as possible in the elderly patient group who do not respond to first\u2010line medical treatment or cannot tolerate medical treatment due to its side effects and who have a high risk of developing PHN compared to other age groups. DRG PRF, applied in the early period of medical treatment\u2010resistant acute HZ, is safe and effective, preventing the progression to PHN.<\/jats:p>","DOI":"10.1155\/2024\/6586167","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T09:40:20Z","timestamp":1725615620000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy and Safety of Pulsed Radiofrequency of Dorsal Root Ganglion in Elderly Patient Population With Acute and Subacute Zoster\u2010Related Pain"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1777-3507","authenticated-orcid":false,"given":"G\u00f6zde","family":"Da\u011f\u0131stan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7508-3616","authenticated-orcid":false,"given":"Serdar","family":"Erdine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-021-02286-6"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/ped.14025"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000000702"},{"key":"e_1_2_13_4_2","first-page":"263","article-title":"Clinical Study of Spinal Cord Stimulation and Pulsed Radiofrequency for Management of Herpes Zoster-Related Pain Persisting Beyond Acute Phase in Elderly Patients","volume":"23","author":"Liu B.","year":"2020","journal-title":"Pain Physician"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.02.029"},{"key":"e_1_2_13_6_2","first-page":"1432","article-title":"Herpes Zoster and Postherpetic Neuralgia: Prevention and Management","volume":"83","author":"Fashner J.","year":"2011","journal-title":"American Family Physician"},{"key":"e_1_2_13_7_2","first-page":"361","article-title":"High-Voltage, Long-Duration Pulsed Radiofrequency on Gasserian Ganglion Improves Acute\/Subacute Zoster-Related Trigeminal Neuralgia: A Randomized, Double-Blinded, Controlled Trial","volume":"22","author":"Wan C.","year":"2019","journal-title":"Pain Physician"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.3344\/kjp.2018.31.4.235"},{"key":"e_1_2_13_9_2","first-page":"313","article-title":"A Clinical Study on the Treatment of Postherpetic Neuralgia With Pulsed Radiofrequency of the Dorsal Root Ganglion With Pain Management","volume":"25","author":"Xiong Z. H.","year":"2020","journal-title":"Neurology Asia"},{"key":"e_1_2_13_10_2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.36076\/ppj.2023.26.E155","article-title":"High-Voltage, Long-Duration Pulsed Radiofrequency to the Dorsal Root Ganglion Provides Improved Pain Relief for Herpes Zoster Neuralgia in the Subacute Stage","volume":"26","author":"Sun C. L.","year":"2023","journal-title":"Pain Physician"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2017.E418"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.12701\/jyms.2022.00101"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0b013e318250f80e"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2011.01162.x"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.2217\/pmt.14.26"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20140210"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1681765"},{"key":"e_1_2_13_18_2","article-title":"Corticosteroids for Preventing Postherpetic Neuralgia","volume":"12","author":"Jiang X.","year":"2023","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_13_19_2","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1111\/ner.13457","article-title":"Comparison of Two Different Pulsed Radiofrequency Modes for Prevention of Postherpetic Neuralgia in Elderly Patients With Acute\/Subacute Trigeminal Herpes Zoster","volume":"25","author":"Wan C. F.","year":"2022","journal-title":"Neuromodulation"},{"key":"e_1_2_13_20_2","article-title":"Effective Treatment of High-Voltage Pulsed Radiofrequency Combined With Oxygen\u2013Ozone Injection in Acute Zoster Neuralgia","volume":"223","author":"Li L. M.","year":"2022","journal-title":"Clinical Neurology and Neurosurgery"},{"key":"e_1_2_13_21_2","article-title":"Comparison of Efficacy of Continuous Epidural Block and Pulsed Radiofrequency to the Dorsal Root Ganglion for Management of Pain Persisting Beyond the Acute Phase of Herpes Zoster","volume":"12","author":"Im E. D.","year":"2017","journal-title":"PLoS One"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S290852"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-022-00946-x"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318182c86e"},{"key":"e_1_2_13_25_2","doi-asserted-by":"crossref","first-page":"262","DOI":"10.36516\/jocass.1299024","article-title":"Investigation of the Effects of Pulsed Radiofrequency Application of the Thoracal Dorsal Root Ganglion on Postherpetic Neuralgia and Post-Thoracotomy Pain Syndromes","volume":"6","author":"Kucukbingoz C.","year":"2023","journal-title":"Journal of Cukurova Anesthesia and Surgical Sciences"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1533-2500.2009.00317.x"},{"key":"e_1_2_13_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000063"}],"container-title":["Pain Research and Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2024\/6586167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T20:59:11Z","timestamp":1732741151000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2024\/6586167"}},"subtitle":[],"editor":[{"given":"Massimiliano","family":"Valeriani","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/2024\/6586167"],"URL":"https:\/\/doi.org\/10.1155\/2024\/6586167","archive":["Portico"],"relation":{},"ISSN":["1203-6765","1918-1523"],"issn-type":[{"value":"1203-6765","type":"print"},{"value":"1918-1523","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2024-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6586167"}}