{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:34:22Z","timestamp":1753886062468,"version":"3.41.2"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":270,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Urology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>We encountered a case of metastatic renal cell carcinoma in which the serum level of KL\u20106, a therapeutic marker, was exceptionally high and fluctuated with the progression of treatment. A 74\u2010year\u2010old man was diagnosed with right renal cystic cancer and multiple metastases in October 2022. The KL\u20106 level was 27490\u2009U\/mL. He started treatment with lenvatinib and pembrolizumab. KL\u20106 decreased to 3885\u2009U\/mg in February 2023. The patient\u2019s proteinuria worsened, leading to the discontinuation of lenvatinib. KL\u20106 increased to 25950\u2009U\/mL in April. He discontinued pembrolizumab and started taking cabozantinib. In September, drug\u2010induced bilateral inflammatory pneumonitis developed. He discontinued cabozantinb and began taking axitinib. KL\u20106 decreased; however, he suffered from severe diarrhea and subsequent renal insufficiency. He discontinued axitinib in November. KL\u20106 increased to 29640\u2009U\/mL in December.<\/jats:p>","DOI":"10.1155\/2024\/6648459","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T09:51:23Z","timestamp":1727430683000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["KL\u20106 Mucin as Serum Tumor Marker of Metastatic Renal Cancer: A Case Report"],"prefix":"10.1155","volume":"2024","author":[{"given":"Kyohei","family":"Ishida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Go","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshinori","family":"Takada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Ogose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5684-8364","authenticated-orcid":false,"given":"Tsutomu","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_13_1_2","DOI":"10.1164\/ajrccm\/148.3.637"},{"doi-asserted-by":"publisher","key":"e_1_2_13_2_2","DOI":"10.1016\/j.resinv.2012.02.001"},{"doi-asserted-by":"publisher","key":"e_1_2_13_3_2","DOI":"10.3390\/ijms22126567"},{"doi-asserted-by":"publisher","key":"e_1_2_13_4_2","DOI":"10.1267\/ahc.12020"},{"doi-asserted-by":"publisher","key":"e_1_2_13_5_2","DOI":"10.3892\/or.2011.1315"},{"doi-asserted-by":"publisher","key":"e_1_2_13_6_2","DOI":"10.1016\/j.bbrc.2018.11.016"},{"key":"e_1_2_13_7_2","first-page":"1013","article-title":"Positive KL-6 mucin expression combined with decreased membranous beta-catenin expression indicates worse prognosis in colorectal carcinoma","volume":"20","author":"Zhang W.","year":"2008","journal-title":"Oncology Reports"},{"key":"e_1_2_13_8_2","first-page":"203","article-title":"Detection of soluble tumor-associated antigens in sera and effusions using novel monoclonal antibodies, KL-3 and KL-6, against lung adenocarcinoma","volume":"18","author":"Kohno N.","year":"1988","journal-title":"Japanese Journal of Clinical Oncology"},{"key":"e_1_2_13_9_2","first-page":"4069","article-title":"Evaluation of serum KL-6, a mucin-like glycoprotein, as a tumor marker for breast cancer","volume":"6","author":"Ogawa Y.","year":"2000","journal-title":"Clinical Cancer Research"}],"container-title":["Case Reports in Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2024\/6648459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T09:51:28Z","timestamp":1727430688000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2024\/6648459"}},"subtitle":[],"editor":[{"given":"Fumitaka","family":"Koga","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/2024\/6648459"],"URL":"https:\/\/doi.org\/10.1155\/2024\/6648459","archive":["Portico"],"relation":{},"ISSN":["2090-696X","2090-6978"],"issn-type":[{"type":"print","value":"2090-696X"},{"type":"electronic","value":"2090-6978"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2024-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6648459"}}