{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T22:53:38Z","timestamp":1768431218737,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":211,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004168","name":"Universit\u00e4t zu L\u00fcbeck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004168","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> The objective of the study is to validate a new human papillomavirus (HPV) L1 high\u2010risk specific serological assay in a case\u2010control study.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Serum samples of 138 patients (cervical intraepithelial neoplasia (CIN) 1, 2, and 3 and cervical cancer), 21 vaccinees, and 246 female controls were tested for the presence of HPV L1 high\u2010risk specific antibodies.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> HPV L1 high\u2010risk antibodies were detected in 100% of the CIN1 and 2, 86.6% of the CIN3 and 82.4% of the cervical cancer cases, 100% of the vaccinees, and 3.9% of the female controls. Area under the curve (AUC) was calculated with 0.91 for controls versus CIN2+, 0.923 for controls versus CIN1+, and 0.968 for controls versus CIN1\/2.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The HPV L1 high\u2010risk specific serological lateral flow rapid test shows promising data in the field of early detection of HPV high\u2010risk induced cervical cancer and its precursor lesions. This easy\u2010to\u2010use, robust, and affordable approach could offer a chance to reach women in low\u2010 or middle\u2010income countries (LMICs) that could not be reached by HPV molecular testing\u2013based cervical cancer screening programs.<\/jats:p>","DOI":"10.1155\/2024\/6651272","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T12:04:28Z","timestamp":1722341068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["CER818: A Highly Specific and Sensitive HPV L1 High\u2010Risk Serological Lateral Flow Rapid Test for Early Detection of Cervical Cancer and Its Precursor Lesions"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8521-9607","authenticated-orcid":false,"given":"Karen","family":"Br\u00e4utigam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Meier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8684-3698","authenticated-orcid":false,"given":"Frank","family":"K\u00f6ster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5904-0486","authenticated-orcid":false,"given":"Achim","family":"Rody","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4342-2495","authenticated-orcid":false,"given":"Ralf","family":"Hilfrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"e_1_2_10_1_2","unstructured":"WHO https:\/\/www.who.int\/news\/item\/04-02-2020-to-eliminate-cervical-cancer-in-the-next-100-years."},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k4823"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(17)30233-5"},{"key":"e_1_2_10_5_2","first-page":"513","article-title":"Comparison of self-collected vaginal, vulvar and urine samples with physician-collected cervical samples for human papillomavirus testing to detect high-grade squamous intraepithelial lesions","volume":"163","author":"Sellors J. 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