{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T14:32:23Z","timestamp":1769524343672,"version":"3.49.0"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education, South Korea","doi-asserted-by":"publisher","award":["2021R1A5A2021614"],"award-info":[{"award-number":["2021R1A5A2021614"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education, South Korea","doi-asserted-by":"publisher","award":["2022M3A9G8018189"],"award-info":[{"award-number":["2022M3A9G8018189"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education, South Korea","doi-asserted-by":"publisher","award":["2020M3A9D3038894"],"award-info":[{"award-number":["2020M3A9D3038894"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education, South Korea","doi-asserted-by":"publisher","award":["KNA 1-2-34, 17-9"],"award-info":[{"award-number":["KNA 1-2-34, 17-9"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011908","name":"Korea National Arboretum","doi-asserted-by":"publisher","award":["2021R1A5A2021614"],"award-info":[{"award-number":["2021R1A5A2021614"]}],"id":[{"id":"10.13039\/501100011908","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011908","name":"Korea National Arboretum","doi-asserted-by":"publisher","award":["2022M3A9G8018189"],"award-info":[{"award-number":["2022M3A9G8018189"]}],"id":[{"id":"10.13039\/501100011908","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011908","name":"Korea National Arboretum","doi-asserted-by":"publisher","award":["2020M3A9D3038894"],"award-info":[{"award-number":["2020M3A9D3038894"]}],"id":[{"id":"10.13039\/501100011908","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011908","name":"Korea National Arboretum","doi-asserted-by":"publisher","award":["KNA 1-2-34, 17-9"],"award-info":[{"award-number":["KNA 1-2-34, 17-9"]}],"id":[{"id":"10.13039\/501100011908","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2024,1,9]]},"abstract":"<jats:p>For centuries, natural products are regarded as vital medicines for human survival. Clematis terniflora var. mandshurica (Rupr.) Ohwi is an ingredient of the herbal medicine, Wei Ling Xian, which has been used in Chinese medicine to alleviate pain, fever, and inflammation. In particular, C. terniflora leaves have been used to cure various inflammatory diseases, including tonsillitis, cholelithiasis, and conjunctivitis. Based on these properties, this study aimed to scientifically investigate the anti-inflammatory effect of an ethanol extract of leaves of C. terniflora (EELCT) using activated macrophages that play central roles in inflammatory response. In this study, EELCT inhibited the essential inflammatory mediators, such as nitric oxide, cyclooxygenase-2, tumor necrosis factor-\u03b1, interleukin- (IL-) 6, IL-1\u03b2, and inducible nitric oxide synthase, by suppressing the nuclear factor-\u03baB and mitogen-activated protein kinase activation in macrophages. Acute lung injury (ALI) is a fatal respiratory disease accompanied by serious inflammation. With high mortality rate, the disease has no effective treatments. Therefore, new therapeutic agents must be developed for ALI. We expected that EELCT can be a promising therapeutic agent for ALI by reducing inflammatory responses and evaluated its action in a lipopolysaccharide- (LPS-) induced ALI model. EELCT alleviated histological changes, immune cell infiltration, inflammatory mediator production, and protein-rich pulmonary edema during ALI. Collectively, our results may explain the traditional usage of C. terniflora in inflammatory diseases and suggest the promising potential of EELCT as therapeutic candidate for ALI.<\/jats:p>","DOI":"10.1155\/2024\/6653893","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T19:50:26Z","timestamp":1704829826000},"page":"1-11","source":"Crossref","is-referenced-by-count":1,"title":["Anti-Inflammatory Effects of Clematis terniflora Leaf on Lipopolysaccharide-Induced Acute Lung Injury"],"prefix":"10.1155","volume":"2024","author":[{"given":"Ji-Yeong","family":"Park","sequence":"first","affiliation":[{"name":"Cell and Matrix Research Institute, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Jong","family":"Kim","sequence":"additional","affiliation":[{"name":"Cell and Matrix Research Institute, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Ae","family":"Choi","sequence":"additional","affiliation":[{"name":"Cell and Matrix Research Institute, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeon-Yong","family":"Kim","sequence":"additional","affiliation":[{"name":"Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup 56212, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup 56212, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Min","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Gardens and Education, Korea National Arboretum, Pocheon 11186, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1819-5913","authenticated-orcid":true,"given":"Sang-Yong","family":"Kim","sequence":"additional","affiliation":[{"name":"DMZ Botanic Garden, Korea National Arboretum, Yanggu 24564, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1882-0256","authenticated-orcid":true,"given":"Gil-Saeng","family":"Jeong","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6160-7354","authenticated-orcid":true,"given":"Sang-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Cell and Matrix Research Institute, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.06.014"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s11434-012-5628-7"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.18219\/ddmh.77.201203.189"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.06.048"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.04.025"},{"key":"6","first-page":"1416","article-title":"Han Ying Ying Han Zhong yi da ci dian = Traditional Chinese medicine dictionary in Chinese-Enghich and English-Chinese. Di 1 ban","volume":"10","author":"F. Zheng","year":"1994","journal-title":"Tianjin: Tianjin da xue chu ban she: Xin hua shu dian Tianjin fa xing suo fa xing"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2016.45"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1186\/s40199-017-0184-y"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/316482"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00705"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/sigtrans.2017.23"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072682"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2016.00028"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2017.09.053"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01722"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105224"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194765"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.11.41"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1586\/ers.10.71"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-022-00500-w"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112484"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000030195"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1089\/jamp.2009.0775"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.669539"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.12.18"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-010-9219-x"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5825"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00071"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7519-8_5"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.2174\/1389203716666150629121324"},{"key":"31","article-title":"Acute respiratory distress syndrome","volume-title":"StatPearls","author":"M. Diamond","year":"2023"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934602"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1177\/09636897221124485"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/s1359-6101(03)00059-5"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2010.00138"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1264913"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402513"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00010.2008"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-125"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1007\/s13258-019-00883-x"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11010"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2018-0101ps"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.9097"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1683996"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12322"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aau6085"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-020-01354-2"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/s1734-1140(13)70976-9"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.7886"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25184073"},{"issue":"5","key":"51","first-page":"2645","article-title":"Kaempferol is an anti-inflammatory compound with activity towards NF-\u03baB pathway proteins","volume":"35","author":"O. Kadioglu","year":"2015","journal-title":"Anticancer Research"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.02.081"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2012.07.007"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2019.4381"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2024\/6653893.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2024\/6653893.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2024\/6653893.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T19:50:30Z","timestamp":1704829830000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2024\/6653893\/"}},"subtitle":[],"editor":[{"given":"R\u00f4mulo Dias","family":"Novaes","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,1,9]]},"references-count":54,"alternative-id":["6653893","6653893"],"URL":"https:\/\/doi.org\/10.1155\/2024\/6653893","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1,9]]}}}