{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:50:57Z","timestamp":1787017857859,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"vor","delay-in-days":159,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    Spontaneous bacterial peritonitis is a life\u2010threatening complication of cirrhosis that can increase healthcare utilization. The impact of albumin administration timing on hospital resource utilization and its optimal timing is unclear, despite its efficacy in improving survival for cirrhosis patients with spontaneous bacterial peritonitis. A retrospective study was conducted to evaluate the influence of the timing of albumin administration on the length of stay and total hospital cost for patients with cirrhosis and spontaneous bacterial peritonitis who require fluid resuscitation. The study utilized de\u2010identified data from Cerner Health Facts\u00ae data. Adult inpatients with a diagnosis of cirrhosis and SBP receiving \u22651 antibiotic and fluid resuscitation between January 1, 2009, and April 30, 2018, were included and stratified by albumin administration timing: \u226424 hours from hospital admission (\u201ctimely albumin\u201d) or &gt;24 hours of admission or no albumin (\u201cnon\u2010timely albumin\u201d). We used a Kaplan\u2010Meier curve with log\u2010rank test to evaluate the association between timing of albumin administration and time to hospital discharge and a generalized linear model to examine the association between albumin timing and total hospital costs. We identified 1,308 hospitalizations, of which 301 contained valid cost data. The timely albumin group had a median time to discharge of 6.95 days compared to 7.78 days in the non\u2010timely group (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.02). Cost model showed that receiving timely albumin incurred 16% lower costs (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.027) than patients in the non\u2010timely albumin group. Timely albumin administration with an antibiotic regimen may shorten the length of stay and lower costs, thereby reducing hospital resource utilization in patients with cirrhosis and spontaneous bacterial peritonitis requiring fluid resuscitation.\n                  <\/jats:p>","DOI":"10.1155\/2024\/6673823","type":"journal-article","created":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T06:20:08Z","timestamp":1717827608000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Timely Albumin Infusion May Improve Resource Utilization in Patients with Cirrhosis and Spontaneous Bacterial Peritonitis"],"prefix":"10.1155","volume":"2024","author":[{"given":"W. 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