{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:02:07Z","timestamp":1785279727041,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhuhai City Social Development Field Science and Technology Plan Project","award":["2320004000308"],"award-info":[{"award-number":["2320004000308"]}]},{"name":"Zhuhai City Social Development Field Science and Technology Plan Project","award":["20231309"],"award-info":[{"award-number":["20231309"]}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["2320004000308"],"award-info":[{"award-number":["2320004000308"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["20231309"],"award-info":[{"award-number":["20231309"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Analytical Chemistry"],"published-print":{"date-parts":[[2024,1,24]]},"abstract":"<jats:p>Serum chitinase-3-like protein 1 (CHI3L1) is a diagnostic marker for liver diseases, such as hepatocellular carcinoma (HCC). Herein, we aimed to evaluate the analytical performance of a chemiluminescent immunoassay (CLIA) for the quantitative detection of CHI3L1 and its application in hepatitis B virus (HBV)-related liver diseases. The CLIA for CHI3L1 detection presented good analytical performance, with a linear range of 1.50\u20132000.00\u2009ng\/mL and a detection limit of 0.98\u2009ng\/mL. To evaluate its clinical application, serum CHI3L1 levels were detected in 82 patients with chronic hepatitis B (CHB) and in 21 healthy controls. The patients with CHB and HCC had higher CHI3L1 levels than the healthy controls and the patients with CHB without HCC. However, CHI3L1 levels did not change significantly with the increase in liver fibrosis stages. The area under the receiver operating characteristic curve for the diagnosis of HBV-related HCC was 0.808, representing a moderate diagnostic value. Correlation analysis revealed a significant association between CHI3L1 and alpha-fetoprotein (AFP) levels, the fibrosis-4 (FIB-4) index, and the aspartate aminotransferase-to-platelet ratio index (APRI). In conclusion, compared with currently reported methods for CHI3L1 detection, the CLIA has a high sensitivity, a wide linear range, and an acceptable accuracy, precision, and reference intervals, making it valuable in the diagnosis of HBV-related HCC.<\/jats:p>","DOI":"10.1155\/2024\/6688819","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T22:20:35Z","timestamp":1706134835000},"page":"1-7","source":"Crossref","is-referenced-by-count":11,"title":["Analytical and Clinical Evaluation of a Chemiluminescent Immunoassay to Detect Serum Chitinase-3-like Protein 1 in HBV-Related Liver Diseases"],"prefix":"10.1155","volume":"2024","author":[{"given":"Yanqiang","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Doumen Qiaoli Hospital of Traditional Chinese Medicine, Zhuhai 519125, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7790-7394","authenticated-orcid":true,"given":"Se","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Guangdong Provincial Hospital of Chinese Medicine, Zhuhai Hospital, Zhuhai 519015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Guangdong Provincial Hospital of Chinese Medicine, Zhuhai Hospital, Zhuhai 519015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Li","sequence":"additional","affiliation":[{"name":"Zhuhai Seesheen Medical Technology Company Limited, Zhuhai 519060, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Guangdong Provincial Hospital of Chinese Medicine, Zhuhai Hospital, Zhuhai 519015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Guangdong Provincial Hospital of Chinese Medicine, Zhuhai Hospital, Zhuhai 519015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0469-7637","authenticated-orcid":true,"given":"Wenzhi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Guangdong Provincial Hospital of Chinese Medicine, Zhuhai Hospital, Zhuhai 519015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5700-1691","authenticated-orcid":true,"given":"Jialing","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Guangdong Provincial Hospital of Chinese Medicine, Zhuhai Hospital, Zhuhai 519015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(14)60220-8"},{"key":"2","first-page":"2648","article-title":"Guidelines on the prevention and treatment in chronic hepatitis B","volume":"12","author":"Chinese Society Of Infectious Diseases","year":"2019","journal-title":"Chinese Journal of Clinical Hepatology"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00303-7"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.760776"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110680"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2015.0037"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23200"},{"key":"8","first-page":"721","article-title":"Guidelines on the management of hepatic encephalopathy in cirrhosis","volume":"10","author":"Chinese Society Of Hepatology","year":"2018","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3227957"},{"key":"10","first-page":"3248","article-title":"Evaluation of chitosinase 3-like protein 1 and its preliminary application in the diagnosis of hepatocellular carcinoma","volume":"32","author":"E. 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