{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T17:14:24Z","timestamp":1787073264943,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":143,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100026234","name":"Big Ten Academic Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100026234","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Obesity"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Weight loss and lifestyle interventions are the mainstay of treatment in pediatric NAFLD. There are gaps in the literature on the objective improvement in BMI to meaningfully impact NAFLD in children.\n                    <jats:italic>Aim<\/jats:italic>\n                    . To determine the decrease in BMI associated with a significant decline in ALT and other metabolic parameters.\n                    <jats:italic>Methods<\/jats:italic>\n                    . Retrospective chart review of pediatric patients with the diagnosis of NAFLD. Data were collected at the baseline and 6 and 12\u2009months. A linear regression model was used to assess the percent change in BMI predictive of change in ALT and other metabolic parameters.\n                    <jats:italic>Results<\/jats:italic>\n                    . 281 charts were included. 71% of patients who had up to a 2.5% loss in BMI at 6\u2009months had a decrease in ALT of up to 10\u2009U\/L compared to 43% patients who did not have a decrease in BMI up to 2.5% loss at the same time period (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.01). The linear regression model showed that 6\u2010month and 12\u2010month percent changes in BMI are predictive of 6\u2010month and 12\u2010month ALT changes (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.01 and 0.02), respectively. ALT normalization was achieved on 12% of patients with a \u22652.5% decrease in BMI at 6\u2009months compared to 1% of patients that had no decrease of \u22652.5% decrease in BMI at 6\u2009months (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.01). The mean BMI\n                    <jats:italic>Z<\/jats:italic>\n                    \u2010score decline was 0.18 (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.001) in the group with a \u22652.5% decrease in BMI at 6\u2009months.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . BMI loss of up to 2.5% and the mean BMI Z\u2010score 0.18 are associated with a significant decrease in ALT of up to 10\u2009U\/L. BMI percent change at 6\u2009months and 12\u2009months is predictive of changes in ALT. These results should help guide providers in clinical practice set objective goals for the management of children with NAFLD resulting from obesity.\n                  <\/jats:p>","DOI":"10.1155\/2024\/6997280","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T19:05:08Z","timestamp":1716491108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between BMI Change, Transaminases, and Other Metabolic Parameters in Children with Nonalcoholic Fatty Liver Disease"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7627-4188","authenticated-orcid":false,"given":"Alvaro G.","family":"Flores Lopez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben 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