{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:57:44Z","timestamp":1785412664964,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":270,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Depression and Anxiety"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Patients with type 2 diabetes mellitus (T2DM) face an increased risk of developing depression and metabolic dysregulation, which can lead to a higher risk of cardiovascular disease (CVD). However, the relationship between the severity of depression and metabolic dysregulation in patients with T2DM remains unclear. This study aimed to investigate this association using data from the ACCORD\u2010health\u2010related quality of life study.<\/jats:p><jats:p><jats:bold>Methods and Results:<\/jats:bold> Patient Health Questionnaire\u20109 (PHQ\u20109) scores and medication regimens were assessed at baseline, 1, 3, and 4 years, and HbA1c, blood pressure, and lipid levels were monitored every 4 months over a 4\u2010year period. The severity of depressive symptoms was categorized as none (0\u20134 points), mild (5\u20139 points), or moderate\u2013severe (10\u201324 points) based on PHQ\u20109 scores. Among the participants, 62% developed depressive symptoms at some point during the 4\u2010year follow\u2010up period, with 21% experiencing persistent depressive symptoms. Participants with moderate\u2010to\u2010severe depression exhibited 0.18% (0.12, 0.24) higher levels of HbA1c, 1.11\u2009mmHg (95% CI, 0.04, 2.15) of SBP, 0.90\u2009mmHg (95% CI, 0.22,1.58) of DBP, and 2.12(95% CI, \u22120.03, 4.27) mg\/dL of LDL, and 0.97 (95% CI, 0.38, 1.56)\u2009mg\/dL lower levels of HDL compared to their counterparts without depressive symptoms. Moreover, as the severity of depressive symptoms increased, variability in HbA1c and blood pressure levels also increased. Furthermore, patients with more severe depressive symptoms demonstrated suboptimal adherence to medication regimens.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Our study found a significant association between depressive symptoms severity and metabolic control in T2DM patients. Greater depressive severity correlated with poorer glycemic, blood pressure, and lipid control, alongside increased variability in these parameters. Additionally, patients with severe depressive symptoms showed suboptimal medication adherence. Addressing mental health in T2DM management is crucial to improve metabolic control and reduce CVD risks.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> ClinicalTrials.gov identifier: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00000620\">NCT00000620<\/jats:ext-link><\/jats:p>","DOI":"10.1155\/2024\/7115559","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T09:35:52Z","timestamp":1727429752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Depressive Symptoms and Metabolic Dysregulation Control: A Closer Look at Control Challenges in T2DM Patients"],"prefix":"10.1155","volume":"2024","author":[{"given":"Yang","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0036-0420","authenticated-orcid":false,"given":"Zhenhua","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.17324"},{"key":"e_1_2_12_2_2","first-page":"223","article-title":"The Relationship Pain Intensity, Anxiety, and Depression in Patients with Fibromyalgia and Rheumatoid Arthritis","volume":"3","author":"Atao\u011flu S.","year":"2002","journal-title":"Anadolu Psikiyatri Dergisi"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-015-0347-4"},{"key":"e_1_2_12_4_2","first-page":"23","article-title":"Prevalence and Predictors of Depression Among Patients With Type 2 Diabetes: A Multicenter Cross-Sectional Study From Bangladesh","volume":"28","author":"Kamrul-Hasan A. 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