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It may be associated with several diseases, such as nonalcoholic fatty liver disease (NAFLD). Polyunsaturated fatty acids (PUFA) are lipid mediators that have anti\u2010inflammatory characteristics and can be found in animals and plants, with capybara oil (CO) being a promising source. So, we intend to evaluate the hepatic pathophysiological alterations in C57Bl\/6 mice with NAFLD, caused by obesity, and the possible beneficial effects of OC in the treatment of this disease. Eighteen 3\u2010month\u2010old male C57Bl\/6 mice received a control or high\u2010fat diet for 18\u2009weeks. From the 15th to the 18th week, the animals received treatment\u2014through orogastric gavage\u2014with placebo or free capybara oil (5\u2009g\/kg). Parameters inherent to body mass, glucose tolerance, evaluation of liver enzymes, percentage of hepatic steatosis, oxidative stress, the process of cell death with the apoptotic biomarkers (Bax, Bcl2, and Cytochrome C), and the ultrastructure of hepatocytes were analyzed. Even though the treatment with CO was not able to disassemble the effects on the physiological parameters, it proved to be beneficial in reversing the morphological and ultrastructural damage present in the hepatocytes. Thus, demonstrating that CO has beneficial effects in reducing steatosis and the apoptotic pathway, it is a promising treatment for NAFLD.<\/jats:p>","DOI":"10.1155\/2024\/7204607","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T20:35:08Z","timestamp":1716842108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Beneficial Effects of Capybara Oil Supplementation on Steatosis and Liver Apoptosis in Obese Mice"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2869-2788","authenticated-orcid":false,"given":"Luciana","family":"Lontro Alves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0480-2604","authenticated-orcid":false,"given":"Priscila","family":"Gomes Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1718-5059","authenticated-orcid":false,"given":"Bianca","family":"Torres Ciambarella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Porto Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7579-7788","authenticated-orcid":false,"given":"K\u00edssila","family":"Rabelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L\u00facia","family":"Rosa Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00edssa","family":"Leal de Carvalho dos Santos Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4320-4252","authenticated-orcid":false,"given":"Cherley","family":"Borba Vieira Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6594-1050","authenticated-orcid":false,"given":"Alan","family":"Cesar Nunes Moraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andressa","family":"Bernardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Verdini Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7867-3131","authenticated-orcid":false,"given":"Jemima","family":"Fuentes Ribeiro da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9426-6381","authenticated-orcid":false,"given":"Jorge","family":"Jos\u00e9 de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(09)60318\u20104"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.706978"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804748"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(11)60814\u20103"},{"key":"e_1_2_11_5_2","unstructured":"World Obesity Federation World obesity Atlas 2023 https:\/\/data.worldobesity.org\/publications\/?cat=19."},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17040481"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010013\u20100758\u20105"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10449"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000004"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.015"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.02.025"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom10121702"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b00529"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.5650\/jos.ess18064"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20070456"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000665"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.7555\/JBR.30.2016K0004"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.15171\/apb.2016.064"},{"key":"e_1_2_11_20_2","unstructured":"de MedeirosM.andIrm\u00e3osD. 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