{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:10:57Z","timestamp":1784020257448,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":162,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Microbiology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Opportunistic infections are the second cause of death among cancer patients. This study aimed at determining the antimicrobial profile and the prevalence of extended\u2010spectrum beta\u2010lactamase (ESBL)\u2010gene carriage of <jats:italic>Pseudomonas aeruginosa<\/jats:italic> isolates among cancer patients at the Douala Laquintinie Hospital, Littoral Region of Cameroon. Between October 2021 and March 2023, 507 study participants were recruited among whom 307 (60.55%) were cancer patients, compared to 200 (39.45%) noncancer patients. Fifty\u2010eight <jats:italic>P. aeruginosa<\/jats:italic> isolates were isolated from fecal samples of forty\u2010five cancer patients and thirteen noncancer patients using Cetrimide agar. The antimicrobial resistance profile of the isolates was determined using the Kirby\u2013Bauer disk diffusion method. The polymerase chain reaction was used to detect the presence of extended\u2010spectrum beta\u2010lactamase genes among <jats:italic>P. aeruginosa<\/jats:italic> isolates. <jats:italic>P. aeruginosa<\/jats:italic> showed significant resistance rates in cancer patients compared to noncancer patients to imipenem, cefotaxime, and ceftazidime, piperacillin\u2010tazobactam, ticarcillin\u2010clavulanic acid, and ciprofloxacin. The multidrug resistance (MDR) rate was significantly (<jats:italic>p<\/jats:italic> &lt; 0.05) higher in cancer patients than in noncancer patients. The frequency of beta\u2010lactamase genes in the 58 ESBL\u2010producing <jats:italic>P. aeruginosa<\/jats:italic> isolates was determined as 72.41% for <jats:italic>b<\/jats:italic><jats:italic>l<\/jats:italic><jats:italic>a<\/jats:italic><jats:sub>TEM<\/jats:sub>, 37.93% for <jats:italic>b<\/jats:italic><jats:italic>l<\/jats:italic><jats:italic>a<\/jats:italic><jats:sub>OXA<\/jats:sub>, 74.14% for bla<jats:sub>CTX\u2010M<\/jats:sub>, and 44.83% for <jats:italic>b<\/jats:italic><jats:italic>l<\/jats:italic><jats:italic>a<\/jats:italic><jats:sub>SHV<\/jats:sub> genes. The study revealed an alarmingly high prevalence of fecal carriage of ESBL\u2010producing <jats:italic>P. aeruginosa<\/jats:italic> with a high rate of MDR among cancer patients. It indicates that regular monitoring and surveillance of ESBL\u2010producing <jats:italic>P. aeruginosa<\/jats:italic> among cancer patients are needed to improve the management of patients.<\/jats:p>","DOI":"10.1155\/2024\/7685878","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T06:08:41Z","timestamp":1718086121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Frequency of Fecal Carriage of ESBL Resistance Genes in Multidrug\u2010Resistant <i>Pseudomonas aeruginosa<\/i> Isolates from Cancer Patients at Laquintinie Hospital, Douala, Littoral Region, Cameroon"],"prefix":"10.1155","volume":"2024","author":[{"given":"Michael F.","family":"Kengne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4178-4967","authenticated-orcid":false,"given":"Armelle T.","family":"Mbaveng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ousenu","family":"Karimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ballue S. T.","family":"Dadjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ornella D.","family":"Tsobeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiliane J. T.","family":"Marbou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1070-1236","authenticated-orcid":false,"given":"Victor","family":"Kuete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21697"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.abr.2022.08.001"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu612"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.4.9809031"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/apm.13010"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.41.3.1192-1202.2003"},{"key":"e_1_2_14_7_2","first-page":"318","article-title":"Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development","volume":"27","author":"Tacconelli E.","year":"2017","journal-title":"World Health Organ"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1371-y"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-2599-1"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-018-2084-1"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.2147\/idr.s198373"},{"key":"e_1_2_14_12_2","first-page":"005","article-title":"Rising antimicrobial resistance of Pseudomonas aeruginosa isolated from clinical specimens in India","volume":"6","author":"Chaudhary M.","year":"2013","journal-title":"Journal of Proteomics & Bioinformatics"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-017-0225-x"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-019-7450-5"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.8648"},{"key":"e_1_2_14_16_2","volume-title":"Foundations in Microbiology","author":"Park Talaro K.","year":"2009"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2008.02.004"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1583510"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1173-2"},{"key":"e_1_2_14_20_2","unstructured":"CLSI Performance standard for antimicrobial susceptibility testing 2023 https:\/\/clsiorg\/media\/1469\/m100s27_samplepdf."},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27292-6"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/5859068"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2015.21.105.5469"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2015.00026"},{"key":"e_1_2_14_25_2","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2013.14.140.1818"},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1306801"},{"key":"e_1_2_14_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2017.05.003"},{"key":"e_1_2_14_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-012-1424-3"},{"key":"e_1_2_14_29_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-509x.175305"},{"key":"e_1_2_14_30_2","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10071-23119"},{"key":"e_1_2_14_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy363"},{"key":"e_1_2_14_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2597-0"},{"key":"e_1_2_14_33_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.036640"},{"key":"e_1_2_14_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.16.6.761"},{"key":"e_1_2_14_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25061340"},{"key":"e_1_2_14_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.14.5.737"},{"key":"e_1_2_14_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-7992(87)90063-7"},{"key":"e_1_2_14_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2005.03.009"},{"key":"e_1_2_14_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-57505-w"},{"key":"e_1_2_14_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8817(87)90051-4"},{"key":"e_1_2_14_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103742"},{"key":"e_1_2_14_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2016.12.004"},{"key":"e_1_2_14_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-018-3196-8"},{"key":"e_1_2_14_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw372"},{"key":"e_1_2_14_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-016-0103-x"},{"key":"e_1_2_14_46_2","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.3809"},{"key":"e_1_2_14_47_2","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.2919"},{"key":"e_1_2_14_48_2","first-page":"859","article-title":"Predominance of CTX-M genotype among extended spectrum beta lactamase isolates in a tertiary hospital in Saudi Arabia","volume":"31","author":"Bindayna K.","year":"2010","journal-title":"Saudi Medical Journal"},{"key":"e_1_2_14_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00971-12"},{"key":"e_1_2_14_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2018.02.002"},{"key":"e_1_2_14_51_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-018-3581-5"}],"container-title":["International Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2024\/7685878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T14:25:52Z","timestamp":1754490352000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2024\/7685878"}},"subtitle":[],"editor":[{"given":"Mohamed Salah","family":"Abbassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/2024\/7685878"],"URL":"https:\/\/doi.org\/10.1155\/2024\/7685878","archive":["Portico"],"relation":{},"ISSN":["1687-918X","1687-9198"],"issn-type":[{"value":"1687-918X","type":"print"},{"value":"1687-9198","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2024-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7685878"}}