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Candida species are typically surface fungi, but in patients with compromised immune systems, they can invade the small intestine and cause angioinvasive infections. A case study involving a 30\u2010year\u2010old female with acute myeloid leukemia (AML) illustrates this phenomenon. The patient was presented with symptoms of abdominal pain, fever, diarrhea, recurrent episodes of intestinal necrosis, hematomas due to thrombocytopenia, and subsequent postoperative enterocutaneous fistulas. Extensive testing ruled out other possible causes of intestinal necrosis and enteritis, including Crohn\u2019s and CMV diseases. <jats:italic>Candida guilliermondi<\/jats:italic> was ultimately identified in blood cultures from the periphery, peritoneal fluid, and intestinal biopsy of respected sections, indicating that it was responsible for intestinal invasion and necrosis. The patient was then treated with amphotericin B, cefepime, and metronidazole. This case highlights the potential severity of fungal infections in immunosuppressed patients, particularly Candida species, and the importance of prompt diagnosis and appropriate treatment.<\/jats:p>","DOI":"10.1155\/2024\/7806235","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T03:49:23Z","timestamp":1721620163000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnosis and Treatment Challenges of <i>Candida guilliermondii<\/i> in Immunocompromised Patients: A Case Study in a Neutropenic AML Patient"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8118-517X","authenticated-orcid":false,"given":"Dhruvi","family":"Modi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Dessureault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Greene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,21]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02528-17"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02084-16"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01451-08"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2111.150404"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.964685"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00099-17"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2022.100944"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/320757"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.7.2129-2133.2001"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.18502\/cmm.5.1.535"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20890"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2013.1.423"},{"key":"e_1_2_7_13_2","first-page":"565","volume-title":"Medical Mycology: The Pathogenic Fungi and the Pathogenic Actinomycetes","author":"Rippon J. 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