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This study is aimed at investigating the therapeutic effect of combination of antiviral therapy with neutralizing monoclonal antibodies for recurrent persistent SARS\u2010CoV\u20102 pneumonia in patients with lymphoma complicated by B cell depletion. A prospective study was conducted on Chinese patients who were treated with antiviral nirmatrelvir\/ritonavir therapy and the neutralizing antibody tixagevimab\u2013cilgavimab (tix\u2010cil). The primary outcome was the rate of recurrent SARS\u2010CoV\u20102 infection. Five patients with lymphoma experienced recurrent SARS\u2010CoV\u20102 pneumonia and received tix\u2010cil treatment. All patients had a history of CD20 monoclonal antibody use within the year preceding SARS\u2010CoV\u20102 infection, and two patients also had a history of Bruton\u2019s tyrosine kinase (BTK) inhibitor use. These patients had notably low lymphocyte counts and exhibited near depletion of B cells. All five patients tested negative for serum SARS\u2010CoV\u20102 IgG and IgM antibodies. None of the patients developed reinfection with SARS\u2010CoV\u20102 pneumonia after antiviral and tix\u2010cil treatment during the 6\u2010month follow\u2010up period. In conclusion, the administration of antiviral and SARS\u2010CoV\u20102\u2010neutralizing antibodies showed encouraging therapeutic efficacy against SARS\u2010CoV\u20102 pneumonia in patients with lymphoma complicated by B cell depletion, along with the potential preventive effect of neutralizing antibodies for up to 6 months.<\/jats:p>","DOI":"10.1155\/2024\/8182887","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T07:49:32Z","timestamp":1722930572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Combination of Antiviral Therapy With Neutralizing Monoclonal Antibodies for Recurrent Persistent SARS\u2010CoV\u20102 Pneumonia in Patients With 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