{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:02:57Z","timestamp":1789988577211,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Xi\u2019an Science and Technology Project","award":["22YXYJ0054"],"award-info":[{"award-number":["22YXYJ0054"]}]},{"name":"Xi\u2019an Science and Technology Project","award":["2024SFYBXM331"],"award-info":[{"award-number":["2024SFYBXM331"]}]},{"name":"Xi\u2019an Science and Technology Project","award":["2024JC-YBMS-623"],"award-info":[{"award-number":["2024JC-YBMS-623"]}]},{"name":"Shaanxi Province Science and Technology Plan Project","award":["22YXYJ0054"],"award-info":[{"award-number":["22YXYJ0054"]}]},{"name":"Shaanxi Province Science and Technology Plan Project","award":["2024SFYBXM331"],"award-info":[{"award-number":["2024SFYBXM331"]}]},{"name":"Shaanxi Province Science and Technology Plan Project","award":["2024JC-YBMS-623"],"award-info":[{"award-number":["2024JC-YBMS-623"]}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["22YXYJ0054"],"award-info":[{"award-number":["22YXYJ0054"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2024SFYBXM331"],"award-info":[{"award-number":["2024SFYBXM331"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2024JC-YBMS-623"],"award-info":[{"award-number":["2024JC-YBMS-623"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2024,5,29]]},"abstract":"<jats:p>Purpose. To investigate the relationship between corneal volume (CV) at different zones and corneal biomechanics in keratoconus (KC) along with the significance of CV in diagnosing and staging KC. Methods. This prospective clinical study included 456 keratoconic eyes (Group B) and 198 normal eyes (Group A). Using the topographic KC classification method, Group B was divided into subgroups based on severity (mild, moderate, and severe). The CVs of the 3\u2009mm, 5\u2009mm, and 7\u2009mm zones and biomechanical parameters were obtained by Pentacam and Corvis ST. The diagnostic utility of multirange CVs at different disease stages and severity was determined using a receiver operating characteristic (ROC) curve analysis. Results. The CV of the 7-mm zone had the strongest correlation with A1V, A2T, PD, DA ratio max (2\u2009mm), DA ratio max (1\u2009mm), ARTh, integrated radius, SPA1, and CBI <jats:inline-formula><a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><a:mfenced open=\"(\" close=\")\" separators=\"|\"><a:mrow><a:mi>p<\/a:mi><a:mo>&lt;<\/a:mo><a:mn>0.01<\/a:mn><\/a:mrow><\/a:mfenced><\/a:math><\/jats:inline-formula>. The CVs of the Group B subgroups were significantly lower than those of Group A for each diameter range <jats:inline-formula><f:math xmlns:f=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><f:mfenced open=\"(\" close=\")\" separators=\"|\"><f:mrow><f:mi>p<\/f:mi><f:mo>&lt;<\/f:mo><f:mn>0.05<\/f:mn><\/f:mrow><\/f:mfenced><\/f:math><\/jats:inline-formula>. There were significant differences between the severe, mild, and moderate subgroups for the 3\u2009mm zone (<jats:inline-formula><k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><k:mi>p<\/k:mi><k:mo>&lt;<\/k:mo><k:mn>0.05<\/k:mn><\/k:math><\/jats:inline-formula>, all). The 3\u2009mm zone CV exhibited better diagnostic ability in each group for distinguishing KC from the normal cornea (Groups A vs. B: area under the ROC curve (AUC)\u2009=\u20090.926, Groups A vs. B1: AUC\u2009=\u20090.894, Groups A vs. B2: AUC\u2009=\u20090.925, Groups A vs. B3: AUC\u2009=\u20090.953). Conclusion. The CV significantly decreased in keratoconic eyes. Progressive thinning in the 3 mm zone may be a valuable measurement for detecting and staging KC. Combining the CV examination with corneal biomechanical information may effectively enhance the ability to detect KC.<\/jats:p>","DOI":"10.1155\/2024\/8422747","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T15:25:34Z","timestamp":1716996334000},"page":"1-7","source":"Crossref","is-referenced-by-count":1,"title":["Correlation between Corneal Volume and Corneal Biomechanics and Corneal Volume Significance in Staging and Diagnosing Keratoconus"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0995-7126","authenticated-orcid":true,"given":"Zhiqing","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Hospital of Shaanxi Normal University, Xi\u2019an 710004, 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Ophthalmology, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7498-0473","authenticated-orcid":true,"given":"Xirui","family":"Su","sequence":"additional","affiliation":[{"name":"Shaanxi Eye Hospital, Xi\u2019an People\u2019s Hospital (Xi\u2019an Fourth Hospital), Affiliated People\u2019s Hospital of Northwest University, Xi\u2019an 710004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5085-2943","authenticated-orcid":true,"given":"Yan","family":"Gao","sequence":"additional","affiliation":[{"name":"Shaanxi Eye Hospital, Xi\u2019an People\u2019s Hospital (Xi\u2019an Fourth Hospital), Affiliated People\u2019s Hospital of Northwest University, Xi\u2019an 710004, 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