{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:36:56Z","timestamp":1790361416153,"version":"4.1.0"},"reference-count":177,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":297,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Malignant tumors, characterized by uncontrolled cell proliferation, are a leading global health challenge, responsible for over 9.7 million deaths in 2022, with new cases expected to rise to 35 million annually by 2050. Immunotherapy is preferred to other cancer therapies, offering precise targeting of malignant cells while simultaneously strengthening the immune system\u2019s complex responses. Advances in this novel field of science have been closely linked to a deeper knowledge of tumor biology, particularly the intricate interplay between tumor cells, the immune system, and the tumor microenvironment (TME), which are central to cancer progression and immune evasion. This review offers a comprehensive analysis of the molecular mechanisms that govern these interactions, emphasizing their critical role in the development of effective immunotherapeutic products. We critically evaluate the current immunotherapy approaches, including cancer vaccines, adoptive T cell therapies, and cytokine\u2010based treatments, highlighting their efficacy and safety. We also explore the latest advancements in combination therapies, which synergistically integrate multiple immunotherapeutic strategies to overcome resistance and enhance therapeutic outcomes. This review offers key insights into the future of cancer immunotherapy with a focus on advancing more effective and personalized treatment strategies.<\/jats:p>","DOI":"10.1155\/2024\/8481761","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T15:33:43Z","timestamp":1729784023000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Tumour Immunotherapy and Applications of Immunological Products: A Review of Literature"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8519-2555","authenticated-orcid":false,"given":"Angus Nnamdi","family":"Oli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9971-5193","authenticated-orcid":false,"given":"Samson Adedeji","family":"Adejumo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8773-5944","authenticated-orcid":false,"given":"Adekunle Babajide","family":"Rowaiye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3323-0657","authenticated-orcid":false,"given":"Joyce Oloaigbe","family":"Ogidigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1982-4416","authenticated-orcid":false,"given":"Jarrad","family":"Hampton-Marcell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7673-2529","authenticated-orcid":false,"given":"Gordon C.","family":"Ibeanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.222"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.12.012"},{"key":"e_1_2_14_3_2","volume-title":"The Cell: A Molecular Approach","author":"Cooper G. M.","year":"2000"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/20503121211034366"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0488-6"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.30982"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11738-0"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-019-0471-y"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01440"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14102524"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25333-9"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.718636"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.35954"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02229"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14153773"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom12060784"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.46747\/cfp.6807515"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2021.0344"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2022.01.005"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13040863"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-0586"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13174447"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.2478\/raon-2022-0002"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05531-1"},{"key":"e_1_2_14_25_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201811"},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-021-03109-w"},{"key":"e_1_2_14_27_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-21-0115"},{"key":"e_1_2_14_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01270-x"},{"key":"e_1_2_14_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00367"},{"key":"e_1_2_14_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176037"},{"key":"e_1_2_14_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15071987"},{"key":"e_1_2_14_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00658-5"},{"key":"e_1_2_14_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2703"},{"key":"e_1_2_14_34_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.808964"},{"key":"e_1_2_14_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3174"},{"key":"e_1_2_14_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0210-z"},{"key":"e_1_2_14_37_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.583084"},{"key":"e_1_2_14_38_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0282"},{"key":"e_1_2_14_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00823-w"},{"key":"e_1_2_14_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0306-5"},{"key":"e_1_2_14_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07195-w"},{"key":"e_1_2_14_42_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.868695"},{"key":"e_1_2_14_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40398-4"},{"key":"e_1_2_14_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00828-5"},{"key":"e_1_2_14_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.03.035"},{"key":"e_1_2_14_46_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.9207.1"},{"key":"e_1_2_14_47_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13061359"},{"key":"e_1_2_14_48_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.610149"},{"key":"e_1_2_14_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/sigtrans.2017.23"},{"key":"e_1_2_14_50_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.985363"},{"key":"e_1_2_14_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01757-9"},{"key":"e_1_2_14_52_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21113949"},{"key":"e_1_2_14_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.025"},{"key":"e_1_2_14_54_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes15020197"},{"key":"e_1_2_14_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00791-1"},{"key":"e_1_2_14_56_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-051113-024537"},{"key":"e_1_2_14_57_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042617-053352"},{"key":"e_1_2_14_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01141-1"},{"key":"e_1_2_14_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2734"},{"key":"e_1_2_14_60_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15235647"},{"key":"e_1_2_14_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.121"},{"key":"e_1_2_14_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00784-1"},{"key":"e_1_2_14_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2020.08.010"},{"key":"e_1_2_14_64_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1344272"},{"key":"e_1_2_14_65_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2000.00121.x"},{"key":"e_1_2_14_66_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.2736"},{"key":"e_1_2_14_67_2","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000239"},{"key":"e_1_2_14_68_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13061440"},{"key":"e_1_2_14_69_2","first-page":"727","article-title":"PD-1\/PD-L1 Pathway: Current Researches in Cancer","volume":"10","author":"Han Y.","year":"2020","journal-title":"American Journal of Cancer Research"},{"key":"e_1_2_14_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm730"},{"key":"e_1_2_14_71_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503093"},{"key":"e_1_2_14_72_2","doi-asserted-by":"publisher","DOI":"10.1177\/1758834016679942"},{"key":"e_1_2_14_73_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1809615"},{"key":"e_1_2_14_74_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13092053"},{"key":"e_1_2_14_75_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14051231"},{"key":"e_1_2_14_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.73"},{"key":"e_1_2_14_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.03.029"},{"key":"e_1_2_14_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00641-0"},{"key":"e_1_2_14_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-01013-0"},{"key":"e_1_2_14_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1471-4906(02)02302-5"},{"key":"e_1_2_14_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.12.001"},{"key":"e_1_2_14_82_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01512"},{"key":"e_1_2_14_83_2","doi-asserted-by":"publisher","DOI":"10.5009\/gnl210311"},{"key":"e_1_2_14_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-024-00522-z"},{"key":"e_1_2_14_85_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2016.151"},{"key":"e_1_2_14_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1093"},{"key":"e_1_2_14_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114212"},{"key":"e_1_2_14_88_2","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-000860"},{"key":"e_1_2_14_89_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9030561"},{"key":"e_1_2_14_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12150"},{"key":"e_1_2_14_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00377-3"},{"key":"e_1_2_14_92_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3175"},{"key":"e_1_2_14_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108114"},{"key":"e_1_2_14_94_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00771"},{"key":"e_1_2_14_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.08.039"},{"key":"e_1_2_14_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.17"},{"key":"e_1_2_14_97_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1699"},{"key":"e_1_2_14_98_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-3323"},{"key":"e_1_2_14_99_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-21-0083"},{"key":"e_1_2_14_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.10.027"},{"key":"e_1_2_14_101_2","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201439246"},{"key":"e_1_2_14_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.11.001"},{"key":"e_1_2_14_103_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48602-6"},{"key":"e_1_2_14_104_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0038-z"},{"key":"e_1_2_14_105_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-021-00787-y"},{"key":"e_1_2_14_106_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15756"},{"key":"e_1_2_14_107_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3818"},{"key":"e_1_2_14_108_2","doi-asserted-by":"publisher","DOI":"10.1177\/15330338211036304"},{"key":"e_1_2_14_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.01.021"},{"key":"e_1_2_14_110_2","doi-asserted-by":"publisher","DOI":"10.2147\/HP.S93413"},{"key":"e_1_2_14_111_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.754196"},{"key":"e_1_2_14_112_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.43"},{"key":"e_1_2_14_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.01.017"},{"key":"e_1_2_14_114_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.166"},{"key":"e_1_2_14_115_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606774"},{"key":"e_1_2_14_116_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.36"},{"key":"e_1_2_14_117_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.5009"},{"key":"e_1_2_14_118_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.2453"},{"key":"e_1_2_14_119_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2016-0487"},{"key":"e_1_2_14_120_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1609214"},{"key":"e_1_2_14_121_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020779"},{"key":"e_1_2_14_122_2","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2021.1908133"},{"key":"e_1_2_14_123_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389450123666211221160632"},{"key":"e_1_2_14_124_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13061383"},{"key":"e_1_2_14_125_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2019.08.002"},{"key":"e_1_2_14_126_2","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2019-CT006"},{"key":"e_1_2_14_127_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00387-y"},{"key":"e_1_2_14_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.06.001"},{"key":"e_1_2_14_129_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.58.3377"},{"key":"e_1_2_14_130_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.112408.134019"},{"key":"e_1_2_14_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101174"},{"key":"e_1_2_14_132_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI146956"},{"key":"e_1_2_14_133_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1917338"},{"key":"e_1_2_14_134_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp288"},{"key":"e_1_2_14_135_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00346-0"},{"key":"e_1_2_14_136_2","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2017-0531"},{"key":"e_1_2_14_137_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001294"},{"key":"e_1_2_14_138_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02894-y"},{"key":"e_1_2_14_139_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-16-0267"},{"key":"e_1_2_14_140_2","volume-title":"StatPearls","author":"Malik B.","year":"2023"},{"key":"e_1_2_14_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.11.058"},{"key":"e_1_2_14_142_2","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201643038"},{"key":"e_1_2_14_143_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12030738"},{"key":"e_1_2_14_144_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1501824"},{"key":"e_1_2_14_145_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801005"},{"key":"e_1_2_14_146_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003466"},{"key":"e_1_2_14_147_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-30472-4_3"},{"key":"e_1_2_14_148_2","doi-asserted-by":"publisher","DOI":"10.3390\/antib9030034"},{"key":"e_1_2_14_149_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00565-9"},{"key":"e_1_2_14_150_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-0116"},{"key":"e_1_2_14_151_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-019-0819-1"},{"key":"e_1_2_14_152_2","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-002449"},{"key":"e_1_2_14_153_2","unstructured":"National Cancer Institute A Phase II Study Using Short-Term Cultured Autologous Tumor-Infiltrating Lymphocytes Following a Lymphodepleting Regimen in Metastatic Cancers Plus the Administration of Pembrolizumab 2023 https:\/\/www.centerwatch.com\/clinical-trials\/listings\/163496\/metastatic-colorectal-cancer-immunotherapy-using-tumor-infiltrating\/?&radius=50."},{"key":"e_1_2_14_154_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1407222"},{"key":"e_1_2_14_155_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709866"},{"key":"e_1_2_14_156_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-019-0070-9"},{"key":"e_1_2_14_157_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2708"},{"key":"e_1_2_14_158_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2725"},{"key":"e_1_2_14_159_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04292-3"},{"key":"e_1_2_14_160_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-018-0328-y"},{"key":"e_1_2_14_161_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-022-00608-8"},{"key":"e_1_2_14_162_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.06.006"},{"key":"e_1_2_14_163_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.675873"},{"key":"e_1_2_14_164_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S301784"},{"key":"e_1_2_14_165_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-91146-7.00010-X"},{"key":"e_1_2_14_166_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10010010"},{"key":"e_1_2_14_167_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-020-02751-0"},{"key":"e_1_2_14_168_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114086"},{"key":"e_1_2_14_169_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2003.01489.x"},{"key":"e_1_2_14_170_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.11.020"},{"key":"e_1_2_14_171_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01242-2"},{"key":"e_1_2_14_172_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00315"},{"key":"e_1_2_14_173_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.736"},{"key":"e_1_2_14_174_2","first-page":"957","volume-title":"Schalm\u2019s Veterinary Hematology","author":"Minin O. V.","year":"2022"},{"key":"e_1_2_14_175_2","doi-asserted-by":"publisher","DOI":"10.21926\/obm.genet.2304206"},{"key":"e_1_2_14_176_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-022-00685-3"},{"key":"e_1_2_14_177_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9060659"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2024\/8481761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T10:14:46Z","timestamp":1736244886000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2024\/8481761"}},"subtitle":[],"editor":[{"given":"Rahul","family":"Shivahare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":177,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/2024\/8481761"],"URL":"https:\/\/doi.org\/10.1155\/2024\/8481761","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2024-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8481761"}}