{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T20:16:53Z","timestamp":1774297013529,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":318,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dermatological Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>With the introduction of fentanyl and xylazine in the drug supply market, injection\u2010related skin injuries and wounds are becoming more common. Xylazine is an alpha\u20102 adrenergic agonist thought to cause deep ulcerative wounds due to peripheral vasoconstriction leading to poor wound healing. This case series describes four patients with injection drug use leading to severe xylazine\u2010related skin injuries who were treated between 2022 and 2023. This paper provides visualization of the extent and severity of these \u201ctranq wounds,\u201d as well as the healing progression when receiving medical treatment, addiction treatment, and wound care. Medical treatment and overall care were complicated by individual social determinants of health. Further understanding of xylazine\u2010related wounds is necessary as xylazine continued to be an emerging threat in the United States. Though some reports in the literature capture the appearances, only few displayed progressive improvements or success in treatment given the challenging nature of treating this high\u2010risk population.<\/jats:p>","DOI":"10.1155\/2024\/8618440","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T09:34:41Z","timestamp":1731576881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Treatment of Xylazine\u2010Associated Injection Skin Injuries"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7188-9738","authenticated-orcid":false,"given":"Ho-Man","family":"Yeung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William Mills","family":"Worrilow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.FORSCIINT.2014.03.015"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/M23-2001"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.JDCR.2023.04.016"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.28160"},{"key":"e_1_2_12_5_2","unstructured":"BettigoleC. FranklinF. andHomJ. Health Alert: Risks of Xylazine Use and Withdrawal in People Who Use Drugs in Philadelphia. Philadelphia Department of Public Health Health Commissioner\u2019s Office."},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.58616\/surgicoll.00002"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12954-024-00978-z"},{"key":"e_1_2_12_8_2","unstructured":"McNinchJ. R. MaguireM. andWallaceL. A Case of Skin Necrosis Caused by Intravenous Xylazine Abuse Journal of Hospital Medicine."},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.orthop.2024.01.004"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/adm.0000000000001245"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmicm2303601"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.12893"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13722-023-00368-z"}],"container-title":["Case Reports in Dermatological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2024\/8618440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T09:34:45Z","timestamp":1731576885000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2024\/8618440"}},"subtitle":[],"editor":[{"given":"Sergio A.","family":"Cuevas Covarrubias","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/2024\/8618440"],"URL":"https:\/\/doi.org\/10.1155\/2024\/8618440","archive":["Portico"],"relation":{},"ISSN":["2090-6463","2090-6471"],"issn-type":[{"value":"2090-6463","type":"print"},{"value":"2090-6471","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2024-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8618440"}}