{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T08:01:45Z","timestamp":1767772905337,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T00:00:00Z","timestamp":1715990400000},"content-version":"vor","delay-in-days":138,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374530"],"award-info":[{"award-number":["82374530"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014978","name":"Hunan University of Chinese Medicine","doi-asserted-by":"publisher","award":["22JBZ046"],"award-info":[{"award-number":["22JBZ046"]}],"id":[{"id":"10.13039\/501100014978","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:italic>Background and Objective<\/jats:italic>. Oral submucous fibrosis (OSF) is a progressive and irreversible disorder of collagen metabolism, resulting in mucosal fibrosis, oral functional changes, and even malignant transformation. This study investigated the relationship between human leukocyte antigen (HLA)\u2010DQB1 alleles and the susceptibility to OSF in a Hunan Han population, providing a new basis for clinical prevention and treatment of OSF. <jats:italic>Methods<\/jats:italic>. 44 OSF patients and 44 healthy volunteers were included in this study. To detect the expression frequency of HLA\u2010DQB1 alleles in the two groups and analyze significant allelic subtypes and their relative risk, polymerase chain reaction (PCR) sequence\u2010specific primers were used. Subsequently, based on the identification of differential genes, we compare the gene expression levels of OSF patients and healthy volunteers expressing differential genes by real\u2010time quantitative PCR. <jats:italic>Results<\/jats:italic>. The expression frequency of the HLA\u2010DQB1<jats:italic>\u2009<\/jats:italic><jats:sup>\u2217<\/jats:sup>05\u2009:\u200902 allele in the OSF group (36.4%) was significantly higher than in the controls (13.6%), and exposure to the HLA\u2010DQB1<jats:italic>\u2009<\/jats:italic><jats:sup>\u2217<\/jats:sup>05\u2009:\u200902 allele was strongly related to OSF (OR (95% CI)\u2009=\u20093.619 (1.257,10.421), Wald <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20095.681, <jats:italic>P<\/jats:italic> = 0.017). However, there were no significant differences in the allele expression frequencies of DQB1<jats:italic>\u2009<\/jats:italic><jats:sup>\u2217<\/jats:sup>02\u2009:\u200901, DQB1<jats:italic>\u2009<\/jats:italic><jats:sup>\u2217<\/jats:sup>03\u2009:\u200903, DQB1<jats:italic>\u2009<\/jats:italic><jats:sup>\u2217<\/jats:sup>05\u2009:\u200901, DQB1<jats:italic>\u2009<\/jats:italic><jats:sup>\u2217<\/jats:sup>05\u2009:\u200903, DQB1<jats:italic>\u2009<\/jats:italic><jats:sup>\u2217<\/jats:sup>06\u2009:\u200902, DQB1<jats:italic>\u2009<\/jats:italic><jats:sup>\u2217<\/jats:sup>06\u2009:\u200903, and DQB1<jats:italic>\u2009<\/jats:italic><jats:sup>\u2217<\/jats:sup>06\u2009:\u200904 in the OSF group compared with the controls (all <jats:italic>P<\/jats:italic> &gt; 0.05). Furthermore, the relative expression level of the HLA\u2010DQB1<jats:italic>\u2009<\/jats:italic><jats:sup>\u2217<\/jats:sup>05\u2009:\u200902 allele in the OSF group (3.98\u2009\u00b1\u20093.50) was significantly higher than in controls (0.70\u2009\u00b1\u20090.41). <jats:italic>Conclusions<\/jats:italic>. There are differences in the HLA\u2010DQB1 allele polymorphisms between the healthy population and patients with oral submucosal fibrosis. Preliminarily, it is suggested that the HLA\u2010DQB1<jats:italic>\u2009<\/jats:italic><jats:sup>\u2217<\/jats:sup>05\u2009:\u200902 allele, which has a strong correlation with OSF and great differential expression between patients with OSF and controls, might be a susceptibility gene for OSF in Hunan.<\/jats:p>","DOI":"10.1155\/2024\/8757860","type":"journal-article","created":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T17:05:07Z","timestamp":1716051907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["HLA\u2010DQB1 Allele Polymorphism Associated with Oral Submucous Fibrosis in Hunan, China"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9817-7634","authenticated-orcid":false,"given":"Yisi","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linkai","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linghang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keke","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuancong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7012-1858","authenticated-orcid":false,"given":"Jin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,18]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2019.06.016"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_131_15"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2013.10.005"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12663\u2010017\u20101056\u20101"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11071793"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100714.1994.tb00258.x"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12043"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.3290\/j.ohpd.a44683"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100714.1995.tb01156.x"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2020.06.010"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1161"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000360855"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3084"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20100039.2011.01770.x"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.2.159"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1590\/s0004\u201027302005000600019"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021055617738"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.99107517"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100714.2000.290304.x"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgg083"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29636"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.4103\/0975\u20107406.191941"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.4103\/0976\u2010237X.166820"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2020.21.7.2055"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/(ISSN)1097\u20100142"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061277"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0904\u20102512.2004.00195.x"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.128"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.5301\/JBM.2012.9937"},{"key":"e_1_2_12_30_2","first-page":"287","article-title":"Gene 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