{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:17:40Z","timestamp":1753888660016,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":207,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Castleman disease (CD) is a rare lymphoproliferative disorder characterized by benign lymph node enlargement. We present the case of a 43\u2010year\u2010old male with a complex medical history, including Crohn\u2019s disease treated with Adalimumab and later complicated with tuberculosis (TB) infection. Subsequently, in May 2021, he was diagnosed with human immunodeficiency virus (HIV) and started on antiretroviral therapy (efavirez, emricitabine, and tenofovir). Despite stropping adalimumab, anti\u2010Tb, and antiviral therapy, he experienced persistent fever, neurological symptoms, and lymphadenopathy. Toxoplasmosis, Cytomegalovirus (CMV), and Human Herpesvirus\u20108 (HHV\u20108) were diagnosed and then treated. Furthermore, the patient displayed intermittent febrile episodes, pancytopenia, altered coagulation parameters, hypoalbuminemia, edema, and generalized abdominal pain, as well as radiological evidence of hepatosplenomegaly and pulmonary infiltrates. Left axillary lymph node biopsy (ALNB) was done and confirmed multicentric castleman disease (MCD). Moreover, the bone marrow aspirate showed plasmocytes. His treatment included chemotherapy with doxorubicin and rituximab while continuing his anti\u2010Tb and antiretroviral therapy. This complex case highlights the diagnostic challenges of managing CD in the presence of multiple coexisting conditions, emphasizing the need for comprehensive evaluation in complex clinical presentations.<\/jats:p>","DOI":"10.1155\/2024\/8817064","type":"journal-article","created":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T03:34:36Z","timestamp":1722051276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Complex Presentation of Multicentric Castleman Disease with Coexisting HIV, HHV\u20108, and Other Opportunistic Infections"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5266-3690","authenticated-orcid":false,"given":"Yehya","family":"Tlaiss","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1515-7038","authenticated-orcid":false,"given":"Hadi","family":"Farhat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8495-1714","authenticated-orcid":false,"given":"Firas","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rami","family":"Yazbek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noura","family":"Shakaroun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nizar","family":"Bitar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195607\/08)9:4<822::AID-CNCR2820090430>3.0.CO;2-4"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000931"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annpat.2022.07.013"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2019.5037"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac481"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2017.09.004"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-018-1656-5"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-023-05116-6"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010801)92:3<670::AID-CNCR1369>3.0.CO;2-Q"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2016.05.006"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1721158"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.30323"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000028077"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2024\/8817064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T03:34:40Z","timestamp":1722051280000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2024\/8817064"}},"subtitle":[],"editor":[{"given":"Pier Paolo","family":"Piccaluga","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/2024\/8817064"],"URL":"https:\/\/doi.org\/10.1155\/2024\/8817064","archive":["Portico"],"relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"type":"print","value":"2090-6560"},{"type":"electronic","value":"2090-6579"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2024-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8817064"}}