{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T19:52:01Z","timestamp":1778010721756,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":296,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Current evidence indicates that some phenotypic characteristics, such as eye or hair color, might be associated with the experience of pain. We, therefore, compared the anesthetic success rate of inferior alveolar nerve block (IANB) and postoperative pain scores between light eyes and dark eyes in female patients who experienced symptomatic irreversible pulpitis (SIP) in a mandibular molar.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This prospective, parallel\u2010group, observational study was registered with ClinicalTrials.gov (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT06206304\">NCT06206304<\/jats:ext-link>). A total of 110 adult female patients who experienced moderate or severe pain with SIP participated in this study. All patients received IANB with 4% articaine with 1:100.000 epinephrine. Endodontic access cavity preparation was initiated after confirmation of IANB. Pain during treatment was recorded by using a Visual Analog Scale. Anesthetic success was recorded as \u201cnone\u201d or \u201cmild\u201d pain. Root canal treatment was performed, with standardized protocols. Postoperative pain scores were also recorded at 24, 48, and 72\u2009h and 7\u2009days after treatment. Statistical analyses of the data were performed using the independent <jats:italic>t<\/jats:italic>\u2010test, repeated measures ANOVA test, and Pearson\u2019s chi\u2010square test. The statistical significance level was set at 0.05.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> No significant differences were found in the success rate of IANB and postoperative pain scores between light\u2010 and dark\u2010eyed patients at any time point (<jats:italic>p<\/jats:italic> &gt; 0.05). The success rate of IANB was 72.73% and 67.27% for light\u2010 and dark\u2010eyed patients, respectively.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Pain scores decreased significantly after RCT in both groups on all days (<jats:italic>p<\/jats:italic> &lt; 0.05). No significant differences were found in the success rate of IANB and postop pain scores between light\u2010 and dark\u2010eyed female patients who experienced SIP in a mandibular molar.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> ClinicalTrials.gov identifier: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT06206304\">NCT06206304<\/jats:ext-link><\/jats:p>","DOI":"10.1155\/2024\/8824366","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T09:20:09Z","timestamp":1729675209000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Eye Color and Postoperative Pain in Female Patients With Symptomatic Irreversible Pulpitis in Mandibular Molars: A Prospective, Parallel\u2010Group, Observational Study"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9432-3809","authenticated-orcid":false,"given":"Merve","family":"Sar\u0131","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6096-7385","authenticated-orcid":false,"given":"Koray","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00457.2012"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.2217\/pmt.15.27"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(94)90189-9"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.43"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200408000-00006"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200503000-00006"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002568"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0730053100"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.08.014"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/184122a0"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2005.00268.x"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/377569"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2004.12.032"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2018.01.009"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.don.0000140576.36513.cb"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12773"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.04.012"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016357.2018.1428826"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-1546.2002.10103.x"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.12.016"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2004.00820.x"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2003.00671.x"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1590\/0103-6440201302115"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13596"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2014.01.103"},{"key":"e_1_2_8_26_2","first-page":"143","article-title":"The Modified Dental Anxiety Scale: Validation and United Kingdom Norms","volume":"12","author":"Humphris G. 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